We target 300+ Biomarkers
to nourish your skin,
balance your gut,
and sharpen your mind.

Your health is interconnected — your skin, gut, and brain work together to shape how you look, feel, and function every day. Nourished3 is the first skincare solution to optimize this connection, addressing imbalances at their root to help you radiate confidence, restore balance, and sharpen your focus. We change the game by shifting the focus from treatment to prevention.

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Support skin cells from UV radiation

Helps protect skin from damage caused by UVA and UVB exposure, which can accelerate premature aging. Supports the skin’s natural defense systems to reduce photoaging and maintain a healthy complexion.

Enhance cellular antioxidant defenses

Boosts the skin’s ability to neutralize harmful free radicals. This reduces oxidative stress, a key factor in visible aging and skin inflammation.

Support strong skin cell membranes and skin cell regeneration

Strengthens the lipid structure of skin cells for resilience against environmental stressors. Encourages healthy turnover of new, vibrant skin cells.

Reduce Transepidermal Water Loss (TEWL)

Helps the skin lock in moisture by reinforcing the protective barrier. This keeps skin hydrated, plump, and less prone to irritation.

Regulate autophagy to support skin cellular longevity

Optimizes the skin’s natural “clean-up” process, removing damaged components from skin cells. This helps maintain youthful, healthy-looking skin over time.

Regulate Matrix Metalloproteinases (MMPs) that break down collagen

Inhibits enzymes that degrade collagen and elastin. This supports skin firmness, elasticity, and a smoother texture.

Enhance skin cell structure and repair

Promotes the production of structural proteins like collagen and elastin. This strengthens the skin’s foundation for long-term health and resilience.

Support healthy skin cell renewal (keratinocyte proliferation)

Encourages the production of new skin cells to maintain a healthy barrier and even tone. This helps skin recover quickly from damage.

Support HSPs (heat shock proteins) to neutralise skin cell damage

Boosts the skin’s natural repair proteins that protect against UV, heat, and oxidative damage. Helps maintain cellular function under stress.

Balance NF-κB and Nrf2 for inflammation and antioxidant support

Balances pathways that control inflammation and antioxidant response. This helps maintain calm, balanced, and protected skin.

Support gut barrier function

Strengthens the intestinal lining to keep harmful substances from entering the bloodstream. A strong gut barrier is essential for reducing skin inflammation linked to gut health.

Enhance expression of TJPs (tight junction proteins)

Boosts the proteins that “seal” the gut lining. This helps prevent leaky gut and its downstream inflammatory effects.

Enhances gut microbiome diversity

Encourages a balanced community of beneficial bacteria. A diverse microbiome supports digestion, nutrient absorption, and skin health.

Reduce oxidative stress and ROS (reactive oxygen species)

Protects gut cells from oxidative damage caused by free radicals. This helps maintain overall gut integrity and function.

Stimulate antioxidant enzymes like glutathione and SOD

Activates the body’s most powerful antioxidant systems to protect gut cells. This reduces inflammation and supports long-term gut health.

Support gut cellular health and bioenergetics

Provides nutrients that fuel gut cells for optimal function. Healthy gut cells improve digestion, immunity, and nutrient delivery to the skin.

Support mitochondrial energy for colon cells

Ensures gut cells have the energy to repair and regenerate. Strong mitochondrial function keeps the digestive system operating efficiently.

Enhance SCFA production (butyrate, propionate, acetate)

Increases beneficial fatty acids that reduce inflammation and support gut barrier integrity. SCFAs also feed healthy bacteria and improve immune balance.

Regulate cortisol to support gut health and brain health

Balances stress hormone levels to protect the gut from stress-related damage. This also benefits mood and skin through the gut–brain–skin axis.

Regulate mood, circadian rhythm and melatonin

Supports balanced mood and healthy sleep-wake cycles. Promotes restorative sleep, which is essential for mental clarity and skin repair.

Reduces oxidative stress and ROS (activate SOD)

Protects brain cells from oxidative damage that can impair cognitive performance. Activates antioxidant pathways like superoxide dismutase (SOD) for lasting neuroprotection.

Enhance brain mitochondrial health and brain energy

Boosts energy production in brain cells for optimal mental performance. Supports focus, memory, and resilience to stress.

Support cellular detoxification

Enhances the brain’s ability to clear waste products and toxins. This helps maintain mental clarity and long-term neurological health.

Regulate cortisol to support mood and stress levels

Balances stress hormones to improve emotional stability. Chronic cortisol elevation can affect mood, focus, and skin health.

Activate key genetic proteins called sirtuins for brain cell longevity 

Stimulates sirtuins, which protect brain cells from aging and stress. Supports long-term cognitive health.

Support brain signalling

Optimizes neurotransmitter function for clear thinking, focus, and positive mood.

Regulate hormone levels

Helps maintain a healthy balance of key hormones that influence mood, cognition, and skin health.

Regulate NMDA receptors

Supports proper brain cell communication and learning capacity. Helps prevent excitotoxicity, a harmful overactivation of neurons.

Increase alpha brain wave activity for relaxation and enhanced alertness

Encourages a calm yet focused mental state. Alpha brain waves are linked to creativity, concentration, and reduced anxiety.

Support DNA methylation

Maintains healthy gene expression in brain cells. This process is vital for brain development, repair, and protection from age-related decline.

Support glymphatic system for refreshed, renewed mornings

Boosts the brain’s nighttime cleansing system to remove waste and toxins. Supports waking up refreshed and mentally clear.

Support autophagy and cellular stress responses

Promotes the recycling of damaged brain cell components. This protects against age-related cognitive decline.

Enhance long term brain health longevity

Protects brain cells from cumulative damage and supports resilience. Encourages sustained mental performance over a lifetime.

Our Science-Backed
Formulas Deliver

Learn More

SCIENCE

  • Targeting over 300+ Biomarkers
  • Supported by 800+ scientific studies
  • Third Party Tested
  • Triple Biotic® Collection

INGREDIENTS

  • Made to EU Standards
  • Clean & Vegan
  • High Bioavailability
  • 80% Active ingredients
  • Non-Comedogenic

Our clinical study examines improvements in the skin microbiome, acne, skin hydration, gut health, and stress resilience

Independent
Clinical Study
12 Weeks
Study
30 Women
(Ages 18-40)
Full Study Coming Soon
 
99%

would recommend the
products to a friend*

98%

strongly agreed skin
looked more radiant* 

100%

reported smoother and
more even skin texture*

92%

noticed fewer
blemishes*

91%

saw overall clearer skin
(tone, texture, breakouts)*

83%

felt skin was more hydrated
throughout the day*

71% 

reported fine lines
appeared less visible*

 

Our results

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The Triple Biotic® Advantage: Prebiotic, Probiotics, a. Postbiotic.

Our Triple Biotic® Skin-Gut-Brain Symbiotic Collection is designed to work in synergy. We use prebiotics to nourish probiotics—live beneficial bacteria—while our skincare contains postbiotics, which are the bioactive compounds produced by these organisms. This combination is essential for creating an environment where they can truly thrive.

2-in-1 Formulation, Superior Delivery

Additionally, most probiotics don’t survive the journey to the gut—but ours do. We use Delayed Release DUOCAP® Technology for added protection. Our acid-resistant dual capsule system, enhanced with BIO-SUPPORT™ fortified probiotic strains, helps ensure that probiotics withstand harsh stomach conditions and reach the colon—where they’re needed most.

Learn More
1

Our Probiotics are
designed to reach

the colon, the best place

for them to grow

2

In an in vitro study,
the majority of our

probiotics survived

the harsh conditions
of the stomach &
small intestine

3

... to be delivered to

the colon

(not stomach)

4

That’s where you
want the bacterias

to arrive and thrive

Your gut microbiome will thank you

Independent Studies on our
Clear Skin® Collection

Sodium Ascorbyl Phosphate (SAP) Stay-C®

Acne Reduction
Study Findings: Double-blind, randomized, vehicle-controlled trial (n=50) showed significant acne improvement over 12 weeks with 5% SAP lotion, with high tolerability compared to placebo.
PubMed: 20367669


Breakouts Begin to Reduce
Study Findings: In a 12-week clinical study, SAP showed early improvements in acne severity by Week 2, especially in inflammatory lesions. Antimicrobial action against C. acnes also helped prevent future breakouts.
PubMed: 20367669


High Efficacy & Safety vs. Prescription Acne Medications
Study Findings: Open-label in vivo study (n=60) using 5% SAP lotion over 12 weeks achieved a 76.9% “excellent or good” rating, outperforming a common prescription acne medication. No side effects reported.
PubMed: 18492184


Anti-Inflammatory & Brightening Effects
Study Findings: 12-week split-face clinical trial with SAP and Ascorbyl Palmitate significantly reduced facial melanin and erythema, confirming brightening and anti-inflammatory benefits.
Source: ResearchGate


Antioxidant & Microbiome Support
Study Findings: In vivo study (n=60) found SAP reduced UVA-induced sebum oxidation by ~40% and demonstrated strong antimicrobial activity against C. acnes, supporting antioxidant and microbiome-balancing effects.
Source: SkinCareRebels Clinical Evidence PDF

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Postbiotic - ACB Modified Pomegranate Enzyme PF™

Cellular Renewal (Leave-On)
Study Findings: 5% enzyme achieved 96.5% pigment normalization in 5 days, comparable to glycolic acid, without irritation.
Source: Cellular Renewal Study (Leave-On)

Accelerated Turnover (Wash-Off)
Study Findings: 4-day trial reduced pigmentation by 14%, comparable to glycolic acid.
Source: Wash-Off Cellular Renewal Study


Improved Hydration
Study Findings: Increased hydration by 9.1% (30 min), 6.8% (2 h), and 4.9% (24 h).
Source: 24-Hour Moisturization Study

Reduced TEWL
Study Findings: Decreased TEWL by 32% (30 min) and 12.1% (24 h).
Source: 24-Hour TEWL Study

Safe for Skin – Cellular Viability
Study Findings: In vitro assay on human keratinocytes showed ACB Modified Pomegranate Enzyme PF™ retained >95% cellular viability at concentrations up to 10%, confirming its non-cytotoxic, skin-compatible profile.
Source: Cell Viability Assay Study

Peptide - Palmitoyl Tripeptide‑38 (Matrixyl® synthe’6)

Wrinkle Reduction & Elasticity
Study Findings: Serum containing Vitamin C, E, and Palmitoyl Tripeptide-38 improved wrinkles, elasticity, and facial aging in photodamaged skin.
Source: PMC7756752

Hydration & Skin Tightening
Study Findings: 3-month trial with Palmitoyl Tripeptide-38 + HA reduced wrinkle depth, increased hydration, and improved skin tightness.
Source: Mattioli Aesthetic Medicine


Peptide Efficacy Trends
Study Findings: Comprehensive reviews confirm Palmitoyl Tripeptide-38 is one of the most scientifically supported anti-aging actives, stimulating collagen synthesis and dermal matrix repair.
Source: Semanticscholar Review

Visible Wrinkle Depth Reduction
Study Findings: 28-day trial showed 23.8% hydration increase, 12.2% wrinkle reduction, and improved elasticity.
Source: Preprints.org

Botanical Amino Acids -  AJIDEW® NL-50

Reduced Post-Cleansing Tightness
Study Findings: 1% AJIDEW® NL-50 reduced tightness and improved comfort after cleansing.
Source: Ajinomoto Technical Brochure (PDF)


Superior Moisture Retention
Study Findings: Absorbs 70% of dry weight in water, outperforming glycerin, HA, betaine, and urea in low humidity.
Source: Rahn Brochure / Ajinomoto Technical Data (PDF)


Barrier & Hydration ImprovementStudy Findings: 2-week use improved hydration and reduced TEWL on cheeks.
Source: Ajinomoto Technical Study, TS data 1002-0380 / 0390 (PDF)


Fine Wrinkle Reduction
Study Findings: 2-week use reduced fine lines on cheeks, confirmed via VISIA® imaging.
Source: Ajinomoto Technical Study, TS data 1002-0400 / 0410 (PDF)


Penetration into the Stratum Corneum
Study Findings: In vivo confocal Raman spectroscopy showed AJIDEW® NL-50 penetrates up to ~10 µm into the stratum corneum, indicating effective delivery of actives into the upper skin barrier.
Source: Ajinomoto Technical Study, TS data 1002-0430 (PDF)

Hyaluronic Acid (Sharohyal® MATRIX)

Increased Hydration & Elasticity
Study Findings: 30-day clinical trial showed +23.8% hydration and 10–15% elasticity improvement in 35 participants.
Source: Preprints.org

Wrinkle Smoothing
Study Findings: 28-day split-face study with 2.5% Sharohyal® MATRIX reduced wrinkle depth by 15.6% within 30 min and maintained 15.1% reduction after 28 days.
Source: Sharon Personal Care


Texture & Firmness Improvement
Study Findings: 12-week HA + peptide regimen improved texture by 79%, reduced wrinkles by 50%, and increased radiance by 44%.
Source: PubMed: 35426967

Lingonberry Extract (Lingostem™)

Antioxidant & Anti-Photoaging Properties
Key finding: Inhibits ROS production and protects against oxidative skin damage.
Study link (PMC5295087)


Collagen Support & Anti-Wrinkle Potential
Key finding: Inhibits MMP-1 and preserves type I collagen under stress.
Study link (PMC9376607)


Barrier Function & Moisturization
Key finding: Significant improvement in hydration, barrier repair, and comfort.
Study summary (Pharmacosmetics Insights)


Blue Light & Digital Pollution Protection
Key finding: Acts as a digital stress defense active, protecting against screen-induced oxidative damage.
Lingostem on Provital


Hydration & Wrinkle Reduction (0.5%)
Study Findings: In vivo study using 0.5% Lingostem™ for 4 weeks showed +44% hydration, 35% wrinkle count reduction, 13% wrinkle volume decrease, and +24% dermal density, supporting firmness and smoothness.
Covalo

Ceramides (EOP, NP, AP)

Barrier Repair & Hydration
Study Findings: 28-day use of ceramide blend (EOP, NP, AP) with cholesterol/fatty acids restored barrier, reduced TEWL, and improved hydration in atopic/dry skin.
Source: MDPI – Cosmetics, 2023


Increased Barrier Resilience
Study Findings: EOP + NP promoted lamellar phase formation, strengthening barrier and reducing TEWL after irritant exposure.
Source: MDPI – Cosmetics, 2023


Improved Barrier Integrity
Study Findings: Correcting NP/AP levels improved water retention and barrier permeability in skin disorders.
Source: PubMed – J Dermatol Sci, 2023


Structural Role of Ceramide EOP in Lipid Matrix Cohesion
Study Findings: Ceramide EOP’s esterified ω-hydroxy structure is essential for forming densely packed long-periodic lamellae, maintaining skin cohesion, hydration, and mechanical strength, and ensuring stratum corneum integrity.
Source: MDPI – Cosmetics, 2023

Ferulic Acid

Photoprotection Enhancement with Antioxidant Blend
Study Findings: Combining 0.5% ferulic acid with 15% vitamin C and 1% vitamin E increased antioxidant efficacy up to 8-fold and improved photostability, defending against oxidative stress and reducing visible photoaging.
Source: Antioxidants in Dermatology, PMC3673383



UV-Induced DNA Damage Reduction
Study Findings: Topical serum with 0.5% ferulic acid, 15% L-ascorbic acid, and 1% α-tocopherol doubled photoprotection versus vitamin C and E alone, significantly reducing UV-induced erythema, thymine dimers, and sunburn cells.
Source: J Invest Dermatol, 2005

Glycerin 

24‑Hour Increased Hydration & Barrier Support
Study Findings: 5% glycerin + 1% hyaluronic acid + Centella asiatica increased hydration by +59% (1 h), +48% (8 h), +29% (24 h) and reduced TEWL by –48% (24 h) in 20 women.
Source: Clin Cosmet Investig Dermatol, 2017

Accelerated Barrier Recovery
Study Findings: Glycerol application after barrier damage normalized TEWL faster and increased hydration over 3–7 days in two in vivo trials.
Source: Acta Derm Venereol, 1999

Improved Hydration & Dermal Thickness
Study Findings: 5% glycerin + 5% xylitol reduced TEWL, increased epidermal/dermal thickness, and improved hydration in 14 days.
Source: Acta Derm Venereol, 2015

Squalane

Increased Hydration & Smoothness
Study Findings: 1–2% squalane increased hydration by up to 51% and reduced roughness in 2 weeks.
Study link (DOI:10.1111/jocd.12606)


Barrier Repair & TEWL Reduction
Study Findings: 1% squalane + glycerin rapidly restored barrier and decreased TEWL.
Study link (DOI:10.1111/srt.12210)

Image

Independent Studies on
Clarify Within®

Vitamin A (Retinyl Palmitate)

Supports Skin Cell Function & Innate Immunity
Key finding: Vitamin A supports skin barrier defense and microbial homeostasis via TLR signaling.
PubMed: 33494277
Full text: PMC7909803


Synergistic Immune Modulation with Vitamin D
Key finding: Vitamins A and D cooperatively regulate immune tolerance, epithelial integrity, and balanced cytokine production.
PubMed: 33494277


Oral Vitamin A for Acne Treatment
Key finding: Oral vitamin A shows strong efficacy in treating acne across multiple trials.
PubMed: 35674761


Restores Gut Barrier in Deficiency
Key finding: Vitamin A is essential for maintaining intestinal barrier function and infection resistance.
PMC Full text: PMC6162863

Vitamin D3 (Veg D3®)

Highly Bioavailable Vegan Vitamin D₃
Key finding: VegD3® is a fast-acting, bioavailable vegan D₃ source equivalent to animal-derived cholecalciferol.
Study summary – AIDP announcement


Vegan-Friendly, Organic, and Potency-Resistant
Key fact: Provides a 1:1 plant-based alternative to lanolin-derived D₃ without loss of efficacy.
AIDP / Nutraceuticals World report


Regulates Skin Immune Function & Cell Proliferation
Key finding: VegD3® supports skin barrier health by balancing inflammatory T-cell responses.
Study link: Exploration Insightful Journals


Modulates Gut Microbiota Composition
Key finding: Oral VegD3® supplementation supports a healthier gut microbiome in a dose-responsive manner.
PubMed: 31892611


Supports Cognitive Function in Mild Cognitive Impairment
Key finding: VegD3® enhances cognition and genomic stability in older adults with MCI.
PubMed: 33164936

Vitamin E (as D-Alpha Tocopherol SunE® 900)

Enhances Skin Photoprotection and Barrier Integrity
Key finding: Vitamin E is a powerful lipid-soluble antioxidant that reinforces skin defense against environmental stress.
PubMed: 17719081 (pubmed.ncbi.nlm.nih.gov)


Boosts Photoprotection via Oral Antioxidant Supplementation
Key finding: Oral vitamin E (with vitamin C) elevates MED and reduces UV-induced erythema.
PubMed: 9448204


Regulates Immune Function and Inflammation
Key finding: Vitamin E supports immune health and antioxidant defense at the cellular level.
PubMed: 17628169 (pubmed.ncbi.nlm.nih.gov)


Modulates T-Cell Function and Inflammatory Response
Key finding: Vitamin E improves adaptive immunity and reduces chronic inflammation.
PubMed: 30501009 (pubmed.ncbi.nlm.nih.gov)

Vitamin K2 (Vital K2®)

Gut Health & Microbiota Modulation
Key finding: Vitamin K supports gut barrier function and microbiome stability, reinforcing mucosal immunity.
DOI: 10.3389/fimmu.2021.791565


Cellular & Mitochondrial Health Benefits
Key finding: Vitamin K₂-7 is a multi-target compound that supports mitochondrial function, vascular protection, and anti-inflammatory resilience.
DOI: 10.3389/fphar.2022.896920


Improves Depression in PCOS Patients
Key finding: Vitamin K₂ may improve mood and emotional well-being in hormonally imbalanced populations.
PubMed: 35883082


Supports Mood Health & Cognitive Function
Key finding: Emerging evidence supports vitamin K’s role in mood regulation, cognitive performance, and neural health.
Full text: PMC128613079

Cerebiome ® Probiotic Blend

Reduces Stress-Related Gut Symptoms
Key finding: The supplement eased GI distress during stress.
PubMed: 19083380


Improves Mood & Reduces Anxiety
Key finding: Lowered anxiety (~25%), depression (~15%), and stress (~20%).
PubMed: 21983070


Improves Stress, Sleep, and Skin Appearance
Key finding: Cerebiome® supports the gut-brain-skin axis by improving mood and sleep while visibly enhancing skin quality.
Study link: PDF


Supports Mood and Increases BDNF in Mild-to-Moderate Depression
Key finding: Cerebiome® may improve depressive symptoms by increasing brain-derived neurotrophic factor (BDNF).
PubMed: 32989186


Enhances Anxiety Reduction in Health-Conscious Adults
Key finding: Cerebiome® may enhance emotional wellbeing when paired with healthy lifestyle behaviors.
Full Text: MDPI – Nutrients


Modulates Brain Activity Under Stress
Key finding: L. helveticus R0052 may influence stress-related brain activity, even without altering cortisol.
PubMed: 35405944


Improves Sleep Quality in Older Adults
Key finding: L. helveticus-fermented milk supports better sleep quality in elderly individuals.
PubMed: 1785146

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Saccharomomyces Boulardii CNCM I-1079

Acne Severity (87% Improved)
Key Finding: 87% of participants had healed or notably improved acne after 4–5 weeks.
PMC: PMC3038963


Inflammatory Lesions & Gut–Acne Link (Mechanistic)
Key Finding: Saccharomyces boulardii significantly reduced inflammatory acne lesions and improved gut-related symptoms.
PubMed: 2530145


Gut–Brain–Skin Axis Mechanism Review
Key Insight: Probiotics reduce inflammation, support the gut barrier, and improve skin outcomes in acne sufferers.
Full Review PDF – PMC3038963


Improves Quality of Life in IBS Patients
Key Finding: S. boulardii significantly enhances quality of life in IBS patients beyond symptom relief.
PubMed: 21301358


Reduces SIBO and Digestive Symptoms in IBS-D
Key Finding: S. boulardii helps reduce SIBO and supports beneficial microbiota shifts in IBS-D.
PubMed: 36630947


Modulates Inflammation and Gut Histology in IBS-D
Key Finding: S. boulardii reduces inflammation and improves gut barrier health in IBS-D.
PubMed: 24722560


Supports Microbiota Regeneration After Diarrhea
Key Finding: S. boulardii CNCM I-745 significantly accelerates microbial recovery and reduces inflammation post-dysbiosis, supporting colonic barrier and microbiome balance.
PubMed: PMID: 26392857 | DOI: 10.2147/CEG.S85574


Prevents Recurrence of C. difficile Infection (CDI)
Key Finding: Co-administering S. boulardii reduced C. difficile relapse from 50% (placebo) to 16.7% in the vancomycin group.
PubMed: 7926463


Reduces Risk of CDI Relapse in High-Risk Patients
Key Finding: CDI recurrence was halved in high-risk patients receiving S. boulardii versus placebo (17% vs. 50%).
PubMed: 10763952


Maintains Microbiome Stability During Antibiotic Use
Key Finding: S. boulardii protected the gut microbiome during antibiotic treatment and prevented digestive side effects.
PubMed Abstract: 25234803


Improves Gut Microbiota in Short Bowel Syndrome (SBS)
Key Finding: S. boulardii enhanced microbial balance and reduced lactic acidosis risk in SBS patients.
PubMed: 25712934


Normalizes Stool Microbiota in Chronic Diarrhea
Key Finding: S. boulardii significantly restored microbiota structure and improved stool form in chronic diarrhea.
PubMed: 18416850

Safr'Inside™

Improves Mood, Well-Being & Stress Response
Key finding: Saffron improved psychological resilience and subjective well-being under psychosocial stress.
ResearchGate Study Link


Rapid Stress Relief via Cortisol Modulation
Key finding: Safr'Inside™ rapidly modulates the HPA axis and lowers cortisol in response to acute stress.
PubMed: PMC10346743


Reduces Acute Stress Response in Healthy Young Men
Key finding: Safr’Inside™ reduces perceived stress and modulates cortisol response under acute stress.
PubMed: 37447245


Improves Mood, HRV, and Stress Resilience
Key finding: Safr’Inside™ improves mood, strengthens stress response, and increases HRV.
PubMed: 33598475


Improves Insomnia and Psychological Stress
Key finding: Safr’Inside™ improves sleep and reduces stress-related symptoms in adults with insomnia.
Study link 1
Study link 2


Enhances Sleep and Gut Microbiome in Older Adults
Key finding: Safr’Inside™ enhances sleep and supports SCFA-producing gut bacteria in older adults.
Study link

Ahiflower® Oil

Boosts Circulating Omega-3s & Immune Modulation
Key finding: Increases anti-inflammatory omega-3 PUFAs and supports immune balance.
PubMed: 28287415


Outperforms Flaxseed Oil in EPA Conversion
Key finding: Ahiflower® converts more efficiently to EPA than flaxseed oil.
PMC: PMC4709838


Stearidonic Acid (SDA) Elevates EPA
Key finding: SDA is a superior omega-3 source for EPA synthesis.
DOI: 10.3389/fnut.2024.1359958


Gut Microbiome Modulation & Prebiotic Effect
Key finding: Supports a healthier microbiome and SCFA-linked gut–brain axis resilience.
PMC: PMC11067990


Enhances Probiotic Survival & SCFA Production
Key finding: Improves probiotic viability and butyrate/propionate production.
PMC: PMC9023356

Borage Oil

Rich in Antioxidants & Anti-Inflammatory Phytochemicals
Key finding: High GLA content and strong free radical scavenging activity linked to skin-calming effects.
Study link (DOI:10.3390/app13042560)


Improves Skin Barrier Function & Reduces Acne Lesions
Key finding: Borage oil improves skin hydration, strengthens barrier function, and reduces acne severity.
PubMed: 24553997

Image

Independent Studies on
Calm Within®

Sensoril® Aswaghanda - Withania somnifera

Reduces Stress & Cortisol in Chronically Stressed Adults
Key finding: Sensoril® lowered stress biomarkers and improved cardiometabolic health.
ResearchGate Link (Full PDF


Lowers Stress & Anxiety
Key finding: Sensoril® reduced stress, anxiety, and cortisol effectively.
PubMed: 23439798


Enhances Cognitive Performance in Stress
Key finding: Sensoril® supports cognition, sleep, and stress response in healthy adults.
PubMed: PMC8632422


Enhances Sleep Quality in Healthy Adults
Key finding: Sensoril® improved sleep duration, quality, and reduced fatigue.
PubMed: 32540634


Supports Cognition & Mood in Healthy Adults
Key finding: Ashwagandha improved cognition and stress markers without side effects.
PubMed: 34838432


Balances Fatigue & Stress in High-Stress Adults
Key finding: Sensoril® helped build stress resilience and reduce fatigue over time.
PubMed: 37740662


Dose-Dependent Reductions in Cortisol & Inflammation
Key finding: Even the lowest dose of Sensoril® significantly reduced stress biomarkers.
ResearchGate Link (Full PDF)


Systematic Review on Stress & Anxiety Outcomes
Key finding: Sensoril® is consistently effective in reducing stress and anxiety in adults.
ScienceDirect Link


Mood-Stabilizing Effects in Anxiety & Depression
Key finding: Sensoril® acts as a mood stabilizer in clinical anxiety and depression.
Journal Link

Quatrefolic® Folic acid as 5-MTHF

Lowers Homocysteine Based on Genetic Profile
Key finding: Folic acid effectively lowers homocysteine, especially in individuals with MTHFR mutations.
PubMed: 9202078


5-MTHF Offers Superior Bioavailability vs. Folic Acid
Key finding: Quatrefolic® provides significantly better absorption than standard folic acid.
PubMed: 27008238


Quatrefolic® Outperforms Folic Acid in Humans
Key finding: Quatrefolic ensures higher systemic availability than folic acid.
Study: ResearchGate Link


Active Folate Improves Cognitive Health in MCI
Key finding: Folate and B vitamins protect cognitive function in at-risk adults.
PubMed: 21780182


Active Folate Bypasses MTHFR Limitations
Key finding: Quatrefolic® directly addresses genetic folate metabolism impairments.
PubMed: 26149435


Quatrefolic® Reduces Homocysteine in Hypertensive Subjects
Key finding: Quatrefolic® is more effective than folic acid in lowering homocysteine.
PubMed: 27655522


Active Folate Enhances Brain & Mood Health
Key finding: 5-MTHF supports mood and cognitive health through methylation and neurotransmitter pathways.
PubMed: 35999905


Folate Improves Skin via Homocysteine Regulation
Key finding: Folate may protect the skin from homocysteine-induced damage.
PubMed: 39919369

Livaux®- Golden Kiwi Fruit

Improves Stool Frequency and Gut Motility
Key finding: Kiwifruit supplementation supports regular bowel movements and gut motility.
PubMed: 25934114
DOI: 10.1016/j.nutres.2015.04.003


Increases Faecalibacterium prausnitzii in Constipated Individuals
Key finding: Kiwifruit supports gut microbiota diversity and anti-inflammatory SCFA production.
DOI: 10.1017/jns.2017.50


Enhances Bowel Function in Healthy Adults
Key finding: Daily gold kiwifruit intake enhances digestive comfort and transit time.
PubMed: 31080591
DOI: 10.1017/jns.2019.1


Improves Digestive & Immune Health in IBS-Constipated and Healthy Subjects
Key finding: Whole-fruit kiwifruit intake supports gut and immune resilience.
PubMed: 32443433
DOI: 10.3390/nu12051453


Treats Chronic Constipation as Effectively as Fiber Supplements
Key finding: Kiwifruit is a natural, well-tolerated therapy for constipation.
PubMed: 36235798
DOI: 10.3390/nu14194146


Supports Mood via Vitamin C
Key finding: Gold kiwifruit positively influences mood and vitality through antioxidant support.
DOI: 10.1017/jns.2013.1


Enhances Iron Absorption in Women with Low Iron Stores
Key finding: Gold kiwifruit enhances non-heme iron absorption in iron-deficient women.
PubMed: 20727238
PMC Full Text – BMC Public Health Supplement (2010)


Supports Gut Health and Butyrate Production via F. prausnitzii
Key finding: Livaux® increased F. prausnitzii levels and improved gastrointestinal symptoms.
PubMed: 29113116
Full text – PMC5672330

Magnesium Bisglycinate

Improves Mood, Sleep & Stress in Chronically Stressed Adults
Key finding: Magnesium + B6 significantly improved sleep quality, mood, and quality of life within 8 weeks.
PubMed: 33864354


Breaks the Stress–Magnesium Deficiency Cycle
Key finding: Magnesium plays a vital role in restoring physiological resilience under chronic stress.
PubMed: 33260549


Reduces UVB-Induced Oxidative Damage in Skin Cells
Key finding: Magnesium supports skin integrity by reducing oxidative stress from UV exposure.
PubMed: 35892565


Alleviates Depressive Symptoms Across Multiple Trials
Key finding: Magnesium offers substantial antidepressant effects across multiple clinical trials.
PubMed: 38213402


Reduces Depression and Anxiety in 6 Weeks
Key finding: Magnesium improved both depression and anxiety symptoms in under 6 weeks.
Link: PLOS ONE


Supports Digestive Health & Bowel Regularity
Key finding: Magnesium contributes to healthy digestion and gut motility.
PubMed: PMC8420003


Crosses the Blood-Brain Barrier to Support Cognitive Health
Key finding: Magnesium bisglycinate enhances brain bioavailability, aiding mood, memory, and mental performance.
DOI: 10.3389/fneur.2020.00543

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Zinc Bisglycinate

Zinc Reduces Inflammatory Skin Conditions
Key finding: Zinc supports immune regulation and reduces skin inflammation in chronic dermatological conditions.
PubMed: 31932842


Zinc Supplementation Improves Acne Outcomes
Key finding: Zinc improves acne severity, particularly in individuals with low baseline levels.
PubMed: 32860489


Zinc as a Therapeutic Agent in Dermatology
Key finding: Zinc is a multi-targeted therapeutic that aids skin barrier function and reduces inflammation.
PubMed: 25120566
Full Text: PMC4120804


Zinc Bisglycinate Offers Superior Bioavailability
Key finding: Zinc bisglycinate is significantly more bioavailable than other common zinc forms.
PubMed: 18271278


Zinc Protects Gut Barrier Integrity
Key finding: Zinc tightens intestinal barriers, reducing gut permeability and supporting microbiome health.
PMC: PMC372437


Zinc Lowers Depression Scores in Clinical Studies
Key finding: Zinc improves mood and reduces depression scores, especially as adjunctive therapy.
ScienceDirect: Link
PubMed: 22534443


Zinc Supports Brain Development and Cognition
Key finding: Zinc plays a vital role in brain health, impacting mood, memory, and executive function.
PubMed: 32829928

CoQ10 (Coenzyme Q10)

Relieves Mild Fatigue in Healthy Adults
Key finding: Ubiquinol-10 supplementation effectively reduced mild fatigue in healthy individuals.
PubMed: 32575770
DOI: 10.3390/nu12061640


Antioxidant Role of CoQ10
Key finding: CoQ10 plays a critical antioxidant role in mitochondrial defense against oxidative stress.
PubMed: 17482888
DOI: 10.1016/j.mito.2007.02.006


Bioenergetic and Antioxidant Effects
Key finding: CoQ10 supports energy metabolism and protects tissues from oxidative damage.
PubMed: 17914161
DOI: 10.1007/s12033-007-0052-y


Supports Skin Health and Microbiome
Key finding: Oral CoQ10 enhances skin integrity and supports a healthy skin microbiome.
PubMed: 30301271
DOI: 10.3390/ijms19103059


CoQ10 in Aging and Disease
Key finding: CoQ10 supplementation may counteract aging-related energy loss and inflammation.
PubMed: 29459830
DOI: 10.3389/fphys.2018.00044


Improves Skin Appearance and Reduces Wrinkles
Key finding: CoQ10 visibly reduces facial wrinkle depth and improves skin elasticity.
PubMed: 27324250
Full Text via ResearchGate


Reduces Oxidative Stress in Skin Cells
Key finding: CoQ10 protects skin from UV-induced oxidative damage.
PubMed: 30216529
PMC: 6266238


Supports Gut Barrier Function
Key finding: CoQ10 preserved intestinal barrier integrity by reducing inflammation.
DOI: 10.1016/j.jss.2015.07.033


Modulates Gut Microbiota and Inflammation
Key finding: CoQ10 modulates gut microbiota and lowers gut-derived inflammation.
DOI: 10.1089/jmf.2019.0171


Protects Brain and Reduces Neuroinflammation
Key finding: CoQ10 may reduce neuroinflammation and support brain energy metabolism.
PubMed: 21555648
PMC: 3096178

L-Theanine (Green Tea)

Reduces Stress, Anxiety & Sleep Disturbances
Key finding: L-Theanine reduced stress, anxiety, and sleep disruption while improving cognitive performance.
PubMed: 31623400


Improves Focus & Cognitive Flexibility in Older Adults
Key finding: L-Theanine improved mental accuracy, focus, and task-switching under cognitive stress.
DOI: 10.1089/jmf.2020.4803


Promotes Relaxation Without Sedation
Key finding: L-Theanine induces calm alertness by increasing alpha brainwave frequency.
PubMed: 18296328


Supports Sleep Quality at Higher Doses
Key finding: L-Theanine improves sleep architecture through stress reduction mechanisms.
PubMed: 17182482


Antioxidant Support for Skin Cells
Key finding: L-Theanine may protect skin from environmental oxidative stress.
PubMed: 28804914


Gut–Brain Axis Modulation & Cortisol Regulation
Key finding: L-Theanine supports relaxation and gut resilience through HPA axis modulation.
PMC: PMC8995781


Systematic Review Confirms Stress & Anxiety Benefits
Key finding: Clinical evidence supports L-Theanine for stress and anxiety relief.
PubMed: 40314930

Bioperine®

Supports Nutrient Absorption & Bioefficacy
Key finding: Piperine improves absorption and systemic bioavailability of co-administered nutrients.
PubMed: 32599787


Boosts Nutrient Bioavailability & Provides Antioxidant Support
Key finding: Piperine enhances bioavailability and provides complementary antioxidant effects.
DOI: 10.3390/app9204270


Neuroprotective Effects Against Oxidative Stress
Key finding: Piperine supports brain health by reducing oxidative stress and inhibiting neurodegenerative pathways.
PubMed: 37237954


Enhances CoQ10 Bioavailability
Key finding: BioPerine® enhanced CoQ10 bioavailability by nearly 30%.
PubMed: 10715596


Improves Selenium Absorption in Healthy Adults
Key finding: BioPerine® significantly improved selenium absorption and maintained stable serum levels.
Source: Sabinsa Research Summary


Protects Skin Cells Against UV-Induced Inflammation (In Vitro)
Key finding: Piperine protects skin cells against UV-related oxidative damage and inflammation.
Source: BioPerine® Research Highlights

Astaxanthin

Astaxanthin Reduces Wrinkles and Improves Skin Elasticity
Key finding: Astaxanthin supplementation reduces visible signs of skin aging.
PubMed: 34578794


Astaxanthin Supports Skin Health and Photoprotection
Key finding: Astaxanthin supports skin health through antioxidant and anti-inflammatory mechanisms.
PubMed: 29690549


Astaxanthin Improves Skin Parameters in Aging Adults
Key finding: Astaxanthin enhances visible skin appearance in aging adults.
PubMed: 2242813

Astaxanthin Enhances Cognitive Function in Middle-Aged Adults
Key finding: Astaxanthin supports cognitive performance and neuroprotection.
PubMed: 29610561


Astaxanthin Boosts Skin Hydration and Elasticity – Meta-Analysis
Key finding: Astaxanthin improves skin hydration and elasticity in clinical settings.
PMC: PMC847273


Astaxanthin Improves Skin Barrier and Reduces Age Spots
Key finding: Astaxanthin improves skin tone and barrier health.
PubMed: 30075283
DOI: 10.3390/nu1007081


Astaxanthin Improves Cognitive Health in Older Adults
Key finding: Astaxanthin supports age-related cognitive performance.
PubMed: 28751807


Astaxanthin and Neurodegenerative Protection – Review
Key finding: Astaxanthin offers neuroprotective benefits through antioxidant activity and BBB permeability.
DOI: 10.3390/nu16060826

Selenium

Supports Cognitive Function in Older Adults
Key finding: Adequate selenium intake is linked to improved cognition in older populations.
PubMed: 37180486
PMCID: PMC10173086


Critical Role in Antioxidant Defense & Anti-Aging
Key finding: Selenium is a critical anti-aging nutrient via antioxidant and cellular protective effects.
DOI: 10.3390/molecules27196613


Enhances Immune Function
Key finding: Selenium sufficiency helps maintain a well-regulated immune system.
PubMed: 35983607


Protects Skin Cells from Oxidative Damage
Key finding: Selenium prevents UV-related skin aging and cellular damage.
PubMed: 2917603


Improves Acne in PCOS-Linked Inflammation
Key finding: Selenium may reduce acne severity in inflammatory-prone populations.
Full Text


Mood Support Through Antioxidant and Neurotransmitter Modulation
Key finding: Selenium acts as a mood modulator and may support emotional well-being.
ResearchGate


Selenium and Mood Regulation
Key finding: Selenium supports mood by modulating oxidative stress and neurochemistry.
DOI: 10.3390/medicina6100003


Protects Skin from UV-Induced Inflammation
Key finding: Selenium reduces photoaging and promotes skin repair.
PMC: 2698273


Regulates Gut Immunity and Inflammation
Key finding: Selenium is essential for gut immune balance and intestinal health.
PubMed: 19152059


Neuroprotection and Brain Health
Key finding: Selenium supports cognitive performance and protects brain structure.
PMC: 9003735

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Ingredients that really make an impact

Our formulas in our skincare and supplementsare clinically proven. We use only the most effective ingredients and keep out unnecessary fillers. We have listed each ingredient for you.

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Scientific Advisory Board

Dr. Amine Zorgani

PhD

Microbiome Expert, with a Ph.D. in Life Sciences and Biotechnology

Dr. Alberto Barbara

PhD

Product Chemist with over 30 years of expertise in the beauty and cosmetic industry

Nicole Barnett

ND

Nutritional Scientist, Bachelor of Health Science, Nutrition and Naturopathic Medicine

Dr. Jennifer Channual

MD

A board-certified medical and cosmetic dermatologist

*Independent consumer study conducted by Nourished3 in August 2025. Results based on 30 participants aged 18–45 after four weeks of use.