Calm Within®

10 min read

Modern life is full of stressors, but what if you could face each day feeling calm, focused, and energized, without burnout? Calm Within® is more than a stress and brain health supplement; it's a comprehensive wellness solution rooted in our proprietary Skin-Gut-Brain Trifecta
 

Whether you’re focused on mental clarity with Clarity Within™ or addressing breakouts and skin inflammation with our Clear Skin collection, Calm Within® serves as the foundational formula that ties it all together, supporting the root systems that influence your mood, complexion, and resilience.
 

Designed to help you manage stress while nourishing your skin, mental health, and body, this advanced formula supports mood balance, cognitive clarity, and long-term vitality—so you can thrive, not just cope.
 

What makes our Calm Within Supplement different

Calm Within® works at the cellular level to support your body's natural systems for energy production, stress regulation, and brain health. Its unique blend of bioactive ingredients is scientifically selected to target three major systems – nervous, digestive, and integumentary, by modulating cortisol, supporting mitochondrial function, and enhancing antioxidant defenses.
 

This one daily ritual delivers layered support across your entire Skin-Gut-Brain Axis. We take a science-first approach, targeting over 300+ skin-gut-brain biomarkers to support longevity, clarity, and total body resilience.
 

What Calm Within offers:

  • Stress relief for calm focus

  • Cellular longevity to fight fatigue

  • Whole-body vitality that radiates outward

 

Capsule technology: Targeted delivery where it matters most

Your mood-balancing, skin-soothing formula uses a fully enteric capsule, meaning it bypasses your stomach and only opens in the intestine, where ingredients are absorbed gently and effectively.

 

Why does our capsule technology matter?

Some of the powerful actives in Calm Within — like Sensoril® Ashwagandha, Livaux® (kiwi prebiotic), CoQ10, zinc, and astaxanthin — can either irritate the stomach or degrade in acid.

By using a delayed-release capsule, we make sure they reach the right place, at the right time — for a calmer gut, balanced stress response, and glowing skin from within.
 

BENEFITS

SKIN:

  • Achieves calm, radiant skin (Zinc, Astaxanthin, CoQ10)

  • Enhances skin hydration and tone (Zinc, Astaxanthin, CoQ10)

  • Supports healthy skin renewal and repair (Quatrefolic, Selenium)

  • Reduces skin redness (Astaxanthin, Zinc)

GUT:

  • Stimulates beneficial bacteria (Livaux, Green Tea)

  • Feeds your microbiome (Livaux)

  • Minimizes digestive discomfort (BioPerine, Livaux)

  • Enhances digestive function (Livaux, BioPerine)

BRAIN:

  • Reduces stress and calms your mind (Sensoril, L-theanine, Magnesium)

  • Supports focus and cognitive clarity (Sensoril, L-theanine, Astaxanthin, CoQ10)

  • Supports relaxation and sleep quality (Magnesium, Sensoril, L-theanine)

  • Protects against oxidative stress (Astaxanthin, Selenium)

 

Why it matters

Calm Within® isn’t just about managing stress, it’s a holistic brain health solution built to support cellular energy, resilience, and mental clarity from the inside out. It does this by targeting critical biological pathways like AMPK activation, mTOR inhibition, and PPAR signaling, which are key to energy production, repair, and antioxidant defense.
 

When you're under acute stress, your body activates the HPA (hypothalamic-pituitary-adrenal) axis, your brain’s way of telling your adrenal glands to produce cortisol. This communication flows all the way down to the mitochondria in adrenal cells, where cortisol is synthesized. That means your brain and your mitochondria must be in sync for a healthy stress response.
 

The mitochondria-stress connection

Mitochondria are more than just your body’s energy factories, they’re deeply involved in hormone production, stress adaptation, and cellular defense. Cortisol, your primary stress hormone, is created inside these mitochondrial "power stations" in the adrenal glands. But stress depletes essential nutrients like B vitamins, vitamin C, selenium, and magnesium, which are required to keep this process running efficiently.

When these systems are out of balance, you start to feel it as:

  • Fatigue and brain fog

  • Slower recovery

  • Mood swings

  • Skin dullness or inflammation

This is why mitochondrial health is the foundation of lasting vitality, and why so many symptoms of stress stem from energy depletion at the cellular level.

 

Fatigue: A cellular signal

Chronic fatigue isn’t just a lack of sleep, it's often a sign that your cells aren’t producing enough ATP (energy). This can happen when your mitochondria are overwhelmed by stress or lacking antioxidant support. 

Stress also increases reactive oxygen species (ROS), which accelerates cellular aging and damages DNA—especially in brain regions like the hippocampus, critical for memory and emotional processing.

 

How Calm Within® supports you

By combining brain-targeted antioxidants like CoQ10, Astaxanthin, and Selenium with adaptogens like Sensoril® Ashwagandha and mitochondrial activators like Magnesium Bisglycinate and PQQ, this formula helps your body:

  • Stay energized and mentally sharp

  • Maintain youthful, hydrated, and resilient skin

  • Build emotional and physical stamina that lasts

Every ingredient works in harmony to optimize your mitochondrial resilience, reinforce your stress response system, and support the skin-gut-brain axis.

 

The science behind the synergy

Mitochondria don’t just produce energy—they respond to stress, regulate hormones, and influence gene expression. They are essential to how your body adapts. In fact:

  • Energy (ATP) powers every level of the stress response—from your genes to your nervous system.

  • Cortisol is both made by and regulated within mitochondria.

  • Mitochondrial function directly shapes how your body and brain react to psychological stress.

  • Better mitochondrial health = stronger, faster, more balanced adaptation.

Put simply: resilient mitochondria make resilient humans.

 

Ingredients and benefits

Each ingredient in Calm Within® is carefully chosen to support the full spectrum of your skin-gut-brain axis. This powerful lineup works synergistically to calm stress, improve digestion, boost cognitive function, and nurture vibrant skin from within.
 

Magnesium Bisglycinate

Stress shouldn’t control your life. With 100mg of Elemental Magnesium (as Bisglycinate), you can:

  • Support a healthy response to daily stress, maintaining a sense of calm and resilience.

  • Enhance feelings of relaxation and positively impact brain pathways linked to stress management.

  • Promote neurotransmitter activity, including serotonin and GABA, for mood stabilization.

  • Deliver a highly absorbable form of magnesium that’s gentle on your digestive system.
     

Did you know? Over 60% of Americans don’t get enough magnesium in their diets, yet this mineral is critical for over 300 biochemical reactions in your body, including heart, bone, and nervous system health.
 

  • Skin: Promotes hydration and reduces inflammation, aiding conditions like acne and eczema.

  • Gut: Supports smooth muscle relaxation, alleviating constipation and promoting regular digestion. Aids motility and soothes the digestive system.

  • Brain: Enhances relaxation and sleep quality, reducing stress and improving cognitive focus. Activates ATP and supports over 300 enzymatic processes for energy production.
     

Highly bioavailable and chelated for optimal absorption, even with age-related or dietary challenges. Ideal for short-term stress management and long-term cellular health.
 

L-Theanine

100mg of L-Theanine brings balance to your day by:

  • Reducing perceived stress and enhancing mental clarity without causing drowsiness.

  • Promoting a relaxed wakefulness through increased alpha brain wave activity.

  • Improving focus, learning performance, and reaction times while decreasing nervous tension.

  • Lowering cortisol levels and supporting neurotransmitter regulation for a brighter mood.
     

Whether you’re managing a busy schedule or seeking deeper relaxation, L-Theanine provides the clarity and calm you need to thrive.

  • Skin: Mitigates stress-related skin issues like acne and inflammation.

  • Gut: Alleviates stress-induced gut dysfunction, supporting a balanced gut-brain axis.

  • Brain: Increases alpha brain waves, promoting calmness, focus, and stress resilience without causing drowsiness.
     

Zinc Bisglycinate

Zinc Bisglycinate (20 mg) - A vital mineral for healing and protecting the body.

  • Skin: Reduces acne, supports wound healing, and enhances overall skin health.

  • Gut: Protects gut lining and supports immune function.

  • Brain: Acts as an antioxidant and supports neurotransmitter production.
     

Quatrefolic® Folate

With 400mcg DFE of Quatrefolic® Folate, you can:

  • Support DNA and RNA synthesis, red blood cell formation, and protein metabolism.

  • Preserve brain health and cognitive function by maintaining healthy homocysteine levels.

  • Aid neurotransmitter synthesis for enhanced mood and emotional resilience.

  • Promote skin cell regeneration, hair vitality, and nail strength.

Folate, in its active form, is immediately bioavailable and plays a vital role in cellular energy and rejuvenation.

  • Skin: Essential for DNA repair and skin cell regeneration, contributing to skin elasticity and healing.

  • Gut: Supports gut lining integrity through cell turnover and repair.

  • Brain: A premium form of folate that supports neurotransmitter production, enhancing mood stability, cognitive function, and overall brain health.
     

Sensoril® Ashwagandha

250mg of Sensoril® Ashwagandha is clinically proven to have anti-inflammatory, anti-stress, antioxidant, immunomodulatory, haemopoietic, and rejuvenating properties.  
 

Human studies have shown a: 
 

  • Reduction in feelings of stress by up to 62%.

  • Improvements in sleep quality by up to 72%, helping you fall asleep faster and stay asleep longer.

  • Lowered cortisol levels by up to 30%, promoting emotional well-being and mental balance.

  • Relief of worry, irritability, and muscle tension while boosting cognition and memory.
     

Experience a calmer, more centered version of yourself with this ancient adaptogen.
 

  • Skin: Reduces cortisol levels, helping with stress-related skin conditions such as premature aging and acne.

  • Gut: Improves gut health by reducing stress-induced inflammation and supporting microbiome balance.

  • Brain: Clinically proven adaptogen that enhances stress resilience, memory, and cognitive performance. Also inhibits mTOR, promoting autophagy and cellular renewal.
     

Ashwagandha is one of the most well-known and studied herbal adaptogens. Studies have also linked ashwagandha with overall lower levels of cortisol. Cortisol, often referred to as the “stress hormone,” works best when it is not too high and not too low.


A study evaluated the benefits of ashwagandha on various stress-related parameters, including food cravings and body weight. After 8 weeks, there was a significant reduction in perceived stress,  improvement in self-reported well-being and happiness, fewer food cravings, and even a reduction in body weight. 


Short-term stress can negatively influence mood, sleep, and appetite levels. Poorly managed stress that occurs over a long period can decrease immunity.
 

Withanolide bioactives in Sensoril® improve brain health by lowering cortisol levels.  As an adaptogen, Ashwagandha promotes resistance to negative stressors and brings the body back into balance, or homeostasis, which is an important mechanism for enhancing cognitive function. 
 

It has long been speculated that a major physiological mechanism responsible for this remarkable activity is the ability of withanolide bioactives to reduce unhealthy levels of cortisol in the body. 
 

The results of a recent randomized, double-blind, placebo-controlled clinical trial using  Sensoril® support its effects. Consumption of Sensoril® at the recommended dose of 250 mg per day reduced the level of serum cortisol in subjects by 24.2%.
 

Antioxidants Reduce Free Radical-Induced Oxidative Damage of Neurons

Free radicals are reactive oxygen species that oxidize and damage cellular components of neurons, including cell membranes, DNA, protein, and mitochondria. An additional damaging effect of cortisol in the brain is that it increases the generation of free radicals while at the same time depressing levels of important antioxidant enzymes that protect the brain against oxidative attack by free radicals, including superoxide dismutase, catalase, and glutathione peroxidase.
 

Regions of the brain that are important for cognitive function, including the cerebral cortex and hippocampus, are particularly vulnerable to oxidative stress.
 

By lowering cortisol levels, Sensoril® produces increased concentrations of the brain’s antioxidant enzymes and greater protection of neurons from free radicals. Sensoril’s antioxidant properties also inhibit oxidative damage by neutralizing free radicals directly.
 

Astaxanthin

6mg of Astaxanthin 5% delivers powerful antioxidant protection to:

  • Improve skin elasticity, hydration, and reduce fine lines and wrinkles.

  • Protect against UV damage and inflammation-induced skin deterioration.

  • Promote healthier skin layers while improving overall tone and luminance.
     

Clinical trials confirm Astaxanthin’s ability to reduce crow’s feet wrinkles, increase moisture, and enhance skin texture—all while supporting cognitive and immune health.
 

  • Skin: A powerful antioxidant that protects against UV damage, reduces wrinkles, improves elasticity, and promotes hydration for a youthful glow.

  • Gut: Reduces inflammation, supporting gut lining integrity and microbiome balance.

  • Brain: Protects brain cells from oxidative stress, supporting cognitive function and reducing neuroinflammation.
     

Livaux® prebiotic

300mg of Livaux® is your secret weapon for:

  • Increasing Faecalibacterium prausnitzii, a vital gut bacteria linked to better digestion and reduced bloating.

  • Enhancing microbiome diversity and promoting a balanced gut environment.

  • Stimulating the growth of healthy gut bacteria for optimal digestive comfort.
     

Your gut is the foundation of your health—let Livaux® help it thrive.
 

Bioperine ®

6mg of Bioperine is clinically proven to enhance bioavailability

  • Skin: Enhances nutrient delivery (e.g., selenium, CoQ10) for antioxidant protection and skin repair. Boosts radiance and supports collagen production.Strengthens hydration and elasticity by improving vitamin absorption.

  • Gut: Optimizes nutrient absorption for better digestion and microbiome balance. Enhances probiotic efficacy and supports gut barrier repair.

  • Brain: Improves bioavailability of nutrients like CoQ10, boosting energy and reducing oxidative stress.Enhances focus, mental clarity, and cognitive protection.
     

Clinical Insights

  • Selenium: 30% higher serum levels with BioPerine®, improving antioxidant defense.

  • CoQ10: 30% increase in absorption, vital for energy and cellular health.
     

CoQ10

100mg of CoQ10 specifically improves:

  • Fatigue in adults and provides cellular energy support.

  • Protection for cell membranes and lipids from free radical stress.

  • Mitochondrial function for sharp focus and memory.

  • Energy production by promoting ATP synthesis, building your body’s energy reserves.

  • Skin: Improves elasticity, reduces wrinkles, and protects against environmental damage for a youthful glow.

  • Gut: Supports digestion, nutrient absorption, and gut lining health by reducing oxidative stress.

  • Brain: Enhances energy production, protects neurons, and boosts cognitive performance and focus.
     

Combined with 5mg of BioPerine®, which enhances nutrient absorption by up to 30%, these ingredients ensure your body gets the most out of every dose. Clinical studies show BioPerine® significantly improves the bioavailability of nutrients like Selenium and CoQ10, optimizing their effectiveness.
 

  • Skin: Enhances bioavailability of skin-beneficial nutrients like antioxidants and vitamins.

  • Gut: Stimulates digestive enzymes, improving nutrient absorption.

  • Brain: Enhances the efficacy of brain-supportive compounds like curcumin and resveratrol. Also activates PPAR pathways to improve metabolism and energy efficiency.
     

Selenium

125mcg of Selenium plays a critical role in:

  • Protecting against oxidative stress and supporting brain health.

  • Boosting immunity and promoting healthy cardiovascular function.

  • Acting as a cofactor for antioxidant enzymes like glutathione peroxidase, safeguarding your cells from damage.
     

Selenium is essential for cell division and overall vitality—don’t let your body go without it.
 

Holistic benefits at a glance

Our expertly formulated blend goes beyond stress relief—it’s a comprehensive wellness solution that nurtures your body from the inside out.
 

  • Healthy Aging: Encourages cellular repair and longevity, promoting youthful skin, robust immunity, and sustained energy.

  • Resilient Cognition: Supports focus, memory, and emotional balance—even under pressure.

  • Brain Vitality: Enhances mitochondrial health, fueling mental clarity and protecting against oxidative stress.

  • Enhanced Quality of Life: Elevates your mood, digestion, and energy, empowering you to live with calm, balance, and vitality.
     

With its unique blend of cutting-edge ingredients, this formula is more than just a stress-relief product—it’s your all-in-one solution for total well-being. 
 

By optimizing pathways like AMPK, mTOR, and PPAR, it supports mitochondrial health, cellular energy, and holistic repair. Take the first step toward a calmer, sharper, and more resilient you today.
 

Each ingredient in this formula has been thoughtfully chosen to deliver targeted support for your skin, gut, and brain, creating a powerful synergy for total well-being. 
 

Say goodbye to stress, fatigue, and dull skin. Say hello to harmony, resilience, and vitality with every capsule
 

Your daily ritual for total wellness

Taking two capsules in the evening is all it takes to initiate your body’s nightly renewal process. The formula works while you rest, delivering targeted support across your body’s most vital systems.
 

SKIN:

  • Promotes clear, radiant complexion

  • Enhances skin hydration, tone, and texture

  • Supports healthy skin renewal and reduced redness

GUT:

  • Balances your skin microbiome

  • Soothes discomfort and bloating

  • Improves regularity and digestive function

BRAIN:

  • Boosts focus and mental clarity

  • Calms the mind and reduces anxiety

  • Supports restorative sleep and emotional resilience

 

For a complete inside-out approach to stress and skin resilience, Calm Within® pairs effectively with Clarity Within™ and our Clear Skin Collection, which deliver complementary support for hormonal balance, detox pathways, and visible skin renewal.
 

Shop all 

 

Disclaimer: These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Meet our Expert

Nicole Barnett, ND

Nicole is a highly experienced Senior Product Executive with nearly 30 years of global expertise in nutraceutical innovation, product formulation, and integrative nutritional science. She has led product development and scientific initiatives across multiple regions including Australia, Asia-Pacific, Europe, and North America, successfully overseeing the creation and launch of groundbreaking nutraceuticals, botanicals, and personalized health solutions.

Her background combines deep scientific knowledge with hands-on experience managing cross-functional teams in R&D, clinical trials, and product innovation. Widely recognized as a thought leader, Nicole has built a strong reputation for transforming cutting-edge research into commercially successful and clinically validated products.

Linkedin