Calm Within®
Calm Within®
Nourished3’s CALM WITHIN® Advanced Skin Support is a first-of-its-kind supplement designed to visibly improve skin by targeting stress and brain health through the skin–gut–brain axis within weeks. Formulated for stressed, acne-prone skin, this science-backed blend supports emotional balance, brain energy, and microbiome health. With Sensoril®, Livaux®, Quatrefolic®, Astaxanthin, Zinc bisglycinate, L-Theanine, and Magnesium bisglycinate, CALM WITHIN® calms the HPA axis, reduces oxidative stress, and restores skin clarity, texture, and hydration — naturally, from within. Your brain-skin reset starts here. Dermatologically tested.
Note: This product already comes in our new packaging.
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Benefits*
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Benefits*
Promotes calm, radiant skin
Soothes irritation for a healthy glow.
Enhances skin hydration & tone
Improves moisture and evenness.
Supports healthy skin renewal & repair
Encourages faster cell turnover.
Reduces skin redness
Calms visible inflammation.
Supplement Facts
+ -Every ingredient and dosage in Nourished3 is verified through independent third-party testing, ensuring that what’s listed on the label is exactly what’s inside. Our formulas meet the stringent EU standards — among the highest in the world — because you deserve the safest, most reliable supplements.
Artificial Colors, Fillers, Common Allergens, Added Sugar, Gluten, Dairy, GMOs, or Contaminants, Third-Party Tested (For Microbes & Heavy Metal)
MADE TO EU STANDARDS
Independent
Clinical Study
12 Weeks
Study
30 Women
(Ages 18-40)
Our results
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What to expect from Calm Within®*
Learn MoreImmediate (Day 1–3)
Reduces cortisol to promote calm and clarity, while increasing relaxation, focus, and cognitive control.
Week 1
Lowers cortisol, eases stress and mood symptoms, and improves sleep quality.
Boosts energy levels and reduces fatigue.
Enhances gut comfort, supports regularity, and activates prebiotic pathways.
Improves skin hydration, reduces inflammatory flare-ups, and strengthens antioxidant defenses.
Week 4
Sustains cortisol regulation, improves calmness, and supports mood stability.
Strengthens SCFA production, improves gut barrier function, and reduces inflammation.
Enhances skin elasticity, hydration, and clarity while boosting antioxidant defense.
Provides ongoing benefits for focus, executive control, and mental clarity.
Week 6
Strengthens the gut barrier, repairs tight junctions, and boosts microbiome diversity and resilience.
Improves mitochondrial energy production and supports immune balance.
Elevates antioxidant activity to protect skin and overall health.
Week 8
Boosts BDNF, supports methylation, and improves mood regulation and cognitive resilience.
Enhances SCFA-driven anti-inflammatory pathways for whole-body support.
Strengthens the skin barrier, refines texture, and promotes brighter tone with reduced pigmentation.
Week 12
Improves HRV, promotes long-term calm, and builds resilience.
Reduces systemic inflammation and skin redness, lowers inflammatory markers, and strengthens antioxidant defense.
Supports collagen production and enhances skin firmness.
Enhances brain performance, neuroprotection, and cognitive clarity.
Trust your gut feeling
Take 2 capsules daily in the evening on an empty stomach. For best results, take for at least 3 months.
Trust your gut feeling
Take 2 capsules daily in the evening on an empty stomach. For best results, take for at least 3 months.
Sensoril®, magnesium, and L-theanine regulate the HPA axis, lower cortisol, and improve focus, calmness, and stress resilience.
CoQ10 boost brain energy (ATP), protect against oxidative stress, and support learning, memory, and attention.
Quatrefolic lowers homocysteine, supports neurotransmitter production, and promotes healthy methylation for optimal brain function.
L-theanine promotes relaxed alertness, reduces anxiety, clears brain fog, and increases calming neurotransmitters like GABA.
Magnesium and CoQ10 enhance mitochondrial health, protect neurons, and improve brain energy and cognition.
Sensoril® and magnesium lower cortisol, support GABA, improve mood, and enhance sleep and energy.
Livaux® nourishes key gut bacteria, boosts SCFA production, and supports microbiome diversity and balance.
Selenium, astaxanthin, and zinc protect skin, enhance hydration, support collagen, and reduce blemishes and pigmentation.
Independent studies on Calm Within
Magnesium Bisglycinate
Improves Mood, Sleep & Stress in Chronically Stressed Adults
Key finding: Magnesium + B6 significantly improved sleep quality, mood, and quality of life within 8 weeks.
PubMed: 33864354
Breaks the Stress–Magnesium Deficiency Cycle
Key finding: Magnesium plays a vital role in restoring physiological resilience under chronic stress.
PubMed: 33260549
Reduces UVB-Induced Oxidative Damage in Skin Cells
Key finding: Magnesium supports skin integrity by reducing oxidative stress from UV exposure.
PubMed: 35892565
Alleviates Depressive Symptoms Across Multiple Trials
Key finding: Magnesium offers substantial antidepressant effects across multiple clinical trials.
PubMed: 38213402
Reduces Depression and Anxiety in 6 Weeks
Key finding: Magnesium improved both depression and anxiety symptoms in under 6 weeks.
Link: PLOS ONE
Supports Digestive Health & Bowel Regularity
Key finding: Magnesium contributes to healthy digestion and gut motility.
PubMed: PMC8420003
Crosses the Blood-Brain Barrier to Support Cognitive Health
Key finding: Magnesium bisglycinate enhances brain bioavailability, aiding mood, memory, and mental performance.
DOI: 10.3389/fneur.2020.00543
L-Theanine
Reduces Stress, Anxiety & Sleep Disturbances
Key finding: L-Theanine reduced stress, anxiety, and sleep disruption while improving cognitive performance.
PubMed: 31623400
Improves Focus & Cognitive Flexibility in Older Adults
Key finding: L-Theanine improved mental accuracy, focus, and task-switching under cognitive stress.
DOI: 10.1089/jmf.2020.4803
Promotes Relaxation Without Sedation
Key finding: L-Theanine induces calm alertness by increasing alpha brainwave frequency.
PubMed: 18296328
Supports Sleep Quality at Higher Doses
Key finding: L-Theanine improves sleep architecture through stress reduction mechanisms.
PubMed: 17182482
Antioxidant Support for Skin Cells
Key finding: L-Theanine may protect skin from environmental oxidative stress.
PubMed: 28804914
Gut–Brain Axis Modulation & Cortisol Regulation
Key finding: L-Theanine supports relaxation and gut resilience through HPA axis modulation.
PMC: PMC8995781
Systematic Review Confirms Stress & Anxiety Benefits
Key finding: Clinical evidence supports L-Theanine for stress and anxiety relief.
PubMed: 40314930
Quatrefolic® Folic acid as 5-MTHF
Lowers Homocysteine Based on Genetic Profile
Key finding: Folic acid effectively lowers homocysteine, especially in individuals with MTHFR mutations.
PubMed: 9202078
5-MTHF Offers Superior Bioavailability vs. Folic Acid
Key finding: Quatrefolic® provides significantly better absorption than standard folic acid.
PubMed: 27008238
Quatrefolic® Outperforms Folic Acid in Humans
Key finding: Quatrefolic ensures higher systemic availability than folic acid.
Full Study: ResearchGate Link
Active Folate Improves Cognitive Health in MCI
Key finding: Folate and B vitamins protect cognitive function in at-risk adults.
PubMed: 21780182
Active Folate Bypasses MTHFR Limitations
Key finding: Quatrefolic® directly addresses genetic folate metabolism impairments.
PubMed: 26149435
Quatrefolic® Reduces Homocysteine in Hypertensive Subjects
Key finding: Quatrefolic® is more effective than folic acid in lowering homocysteine.
PubMed: 27655522
Active Folate Enhances Brain & Mood Health
Key finding: 5-MTHF supports mood and cognitive health through methylation and neurotransmitter pathways.
PubMed: 35999905
Folate Improves Skin via Homocysteine Regulation
Key finding: Folate may protect the skin from homocysteine-induced damage.
PubMed: 39919369
Sensoril® Aswaghanda - Withania somnifera
Reduces Stress & Cortisol in Chronically Stressed Adults
Key finding: Sensoril® lowered stress biomarkers and improved cardiometabolic health.
ResearchGate Link (Full PDF
Lowers Stress & Anxiety
Key finding: Sensoril® reduced stress, anxiety, and cortisol effectively.
PubMed: 23439798
Enhances Cognitive Performance in Stress
Key finding: Sensoril® supports cognition, sleep, and stress response in healthy adults.
PubMed: PMC8632422
Enhances Sleep Quality in Healthy Adults
Key finding: Sensoril® improved sleep duration, quality, and reduced fatigue.
PubMed: 32540634
Supports Cognition & Mood in Healthy Adults
Key finding: Ashwagandha improved cognition and stress markers without side effects.
PubMed: 34838432
Balances Fatigue & Stress in High-Stress Adults
Key finding: Sensoril® helped build stress resilience and reduce fatigue over time.
PubMed: 37740662
Dose-Dependent Reductions in Cortisol & Inflammation
Key finding: Even the lowest dose of Sensoril® significantly reduced stress biomarkers.
ResearchGate Link (Full PDF)
Systematic Review on Stress & Anxiety Outcomes
Key finding: Sensoril® is consistently effective in reducing stress and anxiety in adults.
ScienceDirect Link
Mood-Stabilizing Effects in Anxiety & Depression
Key finding: Sensoril® acts as a mood stabilizer in clinical anxiety and depression.
Journal Link
Bioperine ®
Supports Nutrient Absorption & Bioefficacy
Key finding: Piperine improves absorption and systemic bioavailability of co-administered nutrients.
PubMed: 32599787
Boosts Nutrient Bioavailability & Provides Antioxidant Support
Key finding: Piperine enhances bioavailability and provides complementary antioxidant effects.
DOI: 10.3390/app9204270
Neuroprotective Effects Against Oxidative Stress
Key finding: Piperine supports brain health by reducing oxidative stress and inhibiting neurodegenerative pathways.
PubMed: 37237954
Enhances CoQ10 Bioavailability
Key finding: BioPerine® enhanced CoQ10 bioavailability by nearly 30%.
PubMed: 10715596
Improves Selenium Absorption in Healthy Adults
Key finding: BioPerine® significantly improved selenium absorption and maintained stable serum levels.
Source: Sabinsa Research Summary
Protects Skin Cells Against UV-Induced Inflammation (In Vitro)
Key finding: Piperine protects skin cells against UV-related oxidative damage and inflammation.
Source: BioPerine® Research Highlights
Zinc Bisglycinate
Zinc Reduces Inflammatory Skin Conditions
Key finding: Zinc supports immune regulation and reduces skin inflammation in chronic dermatological conditions.
PubMed: 31932842
Zinc Supplementation Improves Acne Outcomes
Key finding: Zinc improves acne severity, particularly in individuals with low baseline levels.
PubMed: 32860489
Zinc as a Therapeutic Agent in Dermatology
Key finding: Zinc is a multi-targeted therapeutic that aids skin barrier function and reduces inflammation.
PubMed: 25120566
Full Text: PMC4120804
Zinc Bisglycinate Offers Superior Bioavailability
Key finding: Zinc bisglycinate is significantly more bioavailable than other common zinc forms.
PubMed: 18271278
Zinc Protects Gut Barrier Integrity
Key finding: Zinc tightens intestinal barriers, reducing gut permeability and supporting microbiome health.
PMC: PMC372437
Zinc Lowers Depression Scores in Clinical Studies
Key finding: Zinc improves mood and reduces depression scores, especially as adjunctive therapy.
ScienceDirect: Link
PubMed: 22534443
Zinc Supports Brain Development and Cognition
Key finding: Zinc plays a vital role in brain health, impacting mood, memory, and executive function.
PubMed: 32829928
Astaxanthin
Astaxanthin Reduces Wrinkles and Improves Skin Elasticity
Key finding: Astaxanthin supplementation reduces visible signs of skin aging.
PubMed: 34578794
Astaxanthin Supports Skin Health and Photoprotection
Key finding: Astaxanthin supports skin health through antioxidant and anti-inflammatory mechanisms.
PubMed: 29690549
Astaxanthin Improves Skin Parameters in Aging Adults
Key finding: Astaxanthin enhances visible skin appearance in aging adults.
PubMed: 2242813
Astaxanthin Enhances Cognitive Function in Middle-Aged Adults
Key finding: Astaxanthin supports cognitive performance and neuroprotection.
PubMed: 29610561
Astaxanthin Boosts Skin Hydration and Elasticity – Meta-Analysis
Key finding: Astaxanthin improves skin hydration and elasticity in clinical settings.
PMC: PMC847273
Astaxanthin Improves Skin Barrier and Reduces Age Spots
Key finding: Astaxanthin improves skin tone and barrier health.
PubMed: 30075283
DOI: 10.3390/nu1007081
Astaxanthin Improves Cognitive Health in Older Adults
Key finding: Astaxanthin supports age-related cognitive performance.
PubMed: 28751807
Astaxanthin and Neurodegenerative Protection – Review
Key finding: Astaxanthin offers neuroprotective benefits through antioxidant activity and BBB permeability.
DOI: 10.3390/nu16060826
CoQ10
Relieves Mild Fatigue in Healthy Adults
Key finding: Ubiquinol-10 supplementation effectively reduced mild fatigue in healthy individuals.
PubMed: 32575770
DOI: 10.3390/nu12061640
Antioxidant Role of CoQ10
Key finding: CoQ10 plays a critical antioxidant role in mitochondrial defense against oxidative stress.
PubMed: 17482888
DOI: 10.1016/j.mito.2007.02.006
Bioenergetic and Antioxidant Effects
Key finding: CoQ10 supports energy metabolism and protects tissues from oxidative damage.
PubMed: 17914161
DOI: 10.1007/s12033-007-0052-y
Supports Skin Health and Microbiome
Key finding: Oral CoQ10 enhances skin integrity and supports a healthy skin microbiome.
PubMed: 30301271
DOI: 10.3390/ijms19103059
CoQ10 in Aging and Disease
Key finding: CoQ10 supplementation may counteract aging-related energy loss and inflammation.
PubMed: 29459830
DOI: 10.3389/fphys.2018.00044
Improves Skin Appearance and Reduces Wrinkles
Key finding: CoQ10 visibly reduces facial wrinkle depth and improves skin elasticity.
PubMed: 27324250
Full Text via ResearchGate
Reduces Oxidative Stress in Skin Cells
Key finding: CoQ10 protects skin from UV-induced oxidative damage.
PubMed: 30216529
PMC: 6266238
Supports Gut Barrier Function
Key finding: CoQ10 preserved intestinal barrier integrity by reducing inflammation.
DOI: 10.1016/j.jss.2015.07.033
Modulates Gut Microbiota and Inflammation
Key finding: CoQ10 modulates gut microbiota and lowers gut-derived inflammation.
DOI: 10.1089/jmf.2019.0171
Protects Brain and Reduces Neuroinflammation
Key finding: CoQ10 may reduce neuroinflammation and support brain energy metabolism.
PubMed: 21555648
PMC: 3096178
Selenium
Supports Cognitive Function in Older Adults
Key finding: Adequate selenium intake is linked to improved cognition in older populations.
PubMed: 37180486
PMCID: PMC10173086
Critical Role in Antioxidant Defense & Anti-Aging
Key finding: Selenium is a critical anti-aging nutrient via antioxidant and cellular protective effects.
DOI: 10.3390/molecules27196613
Enhances Immune Function
Key finding: Selenium sufficiency helps maintain a well-regulated immune system.
PubMed: 35983607
Protects Skin Cells from Oxidative Damage
Key finding: Selenium prevents UV-related skin aging and cellular damage.
PubMed: 2917603
Improves Acne in PCOS-Linked Inflammation
Key finding: Selenium may reduce acne severity in inflammatory-prone populations.
Full Text
Mood Support Through Antioxidant and Neurotransmitter Modulation
Key finding: Selenium acts as a mood modulator and may support emotional well-being.
ResearchGate
Selenium and Mood Regulation
Key finding: Selenium supports mood by modulating oxidative stress and neurochemistry.
DOI: 10.3390/medicina6100003
Protects Skin from UV-Induced Inflammation
Key finding: Selenium reduces photoaging and promotes skin repair.
PMC: 2698273
Regulates Gut Immunity and Inflammation
Key finding: Selenium is essential for gut immune balance and intestinal health.
PubMed: 19152059
Neuroprotection and Brain Health
Key finding: Selenium supports cognitive performance and protects brain structure.
PMC: 9003735
Livaux®- Golden Kiwi Fruit (Actinidia chinensis)
Improves Stool Frequency and Gut Motility
Key finding: Kiwifruit supplementation supports regular bowel movements and gut motility.
PubMed: 25934114
DOI: 10.1016/j.nutres.2015.04.003
Increases Faecalibacterium prausnitzii in Constipated Individuals
Key finding: Kiwifruit supports gut microbiota diversity and anti-inflammatory SCFA production.
DOI: 10.1017/jns.2017.50
Enhances Bowel Function in Healthy Adults
Key finding: Daily gold kiwifruit intake enhances digestive comfort and transit time.
PubMed: 31080591
DOI: 10.1017/jns.2019.1
Improves Digestive & Immune Health in IBS-Constipated and Healthy Subjects
Key finding: Whole-fruit kiwifruit intake supports gut and immune resilience.
PubMed: 32443433
DOI: 10.3390/nu12051453
Treats Chronic Constipation as Effectively as Fiber Supplements
Key finding: Kiwifruit is a natural, well-tolerated therapy for constipation.
PubMed: 36235798
DOI: 10.3390/nu14194146
Supports Mood via Vitamin C
Key finding: Gold kiwifruit positively influences mood and vitality through antioxidant support.
DOI: 10.1017/jns.2013.1
Enhances Iron Absorption in Women with Low Iron Stores
Key finding: Gold kiwifruit enhances non-heme iron absorption in iron-deficient women.
PubMed: 20727238
PMC Full Text – BMC Public Health Supplement (2010)
Supports Gut Health and Butyrate Production via F. prausnitzii
Key finding: Livaux® increased F. prausnitzii levels and improved gastrointestinal symptoms.
PubMed: 29113116
Full text – PMC5672330
We shift the focus from treatment to prevention
Supplements alone aren’t a long-term fix. They nourish, balance, and restore from within — but without topical care, they can’t fully protect or strengthen the skin barrier. That’s why at Nourished3, we believe in integrating both: inner support through supplements and outer support through skincare.
Our supplements are powerful and clinically backed. The gut supplement supports microbiome diversity and reduces inflammation, while the brain supplement calms stress and restores balance. Together, they build a strong internal foundation for clear, radiant skin. But lasting transformation happens when supplements are paired with topical care — skincare that strengthens the barrier and amplifies internal results for visible, long-term clarity.
This philosophy is the foundation of our Trifecta Method™, designed to nourish the skin–gut–brain connection from every angle. It comes to life through our Triple Biotic™ Symbiotic Collection:
Step 1 (Skin): Postbiotic skincare, Step 2 (Gut): Probiotic gut supplement, Step 3 (Brain): Prebiotic brain supplement
Together, this system goes beyond surface or internal care alone — delivering truly holistic results that help your skin thrive, stay radiant, and flourish from the inside out.
Shop the Skin–Gut–Brain System
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Learn, Nourish, Glow and Thrive
Frequently asked questions
1. What is Calm Within™?
Calm Within™ is a science-backed supplement designed to help you stress less, focus better, sleep deeper, and glow brighter — all by targeting the skin–gut–brain axis™. Its unique blend of clinically studied adaptogens, antioxidants, minerals, and prebiotics works to regulate cortisol, support mitochondrial health, protect against oxidative stress, and strengthen your skin barrier from within.
2. How do I take it?
Adults 18+ should take two capsules daily in the evening on an empty stomach with a glass of water. For best results, use consistently for at least 3 months.
3. When will I see results?
Some users notice a calmer mood, reduced stress, or better sleep within 1–2 weeks. Skin hydration, gut balance, and overall resilience typically become more visible after 6–12 weeks of consistent use, in line with clinical studies on the ingredients.
4. What makes Calm Within™ different from other supplements?
Unlike standard stress or sleep supplements, Calm Within™ is built on the Skin–Gut–Brain Axis™ approach. It includes patented actives like Sensoril® Ashwagandha, Quatrefolic® Folate, Livaux®, BioPerine®, and Astaxanthin — all delivered in a delayed-release capsule that protects sensitive ingredients, optimizes mineral absorption, and enhances bioavailability for maximum efficacy.
5. How long does one bottle last?
Each bottle contains 60 capsules, which is a 30-day supply.
6. Can I take Calm Within™ with other supplements?
Yes, Calm Within™ can be taken alongside most supplements. For best results, we recommend combining it with:
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I SKIN (Clear Skin Collection skincare)
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II GUT (Clarify Within® supplement)
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Together, they provide full Skin–Gut–Brain Axis™ support through our Triple Biotic™ synergy system.
If you are on prescription medication, pregnant, or breastfeeding, consult your healthcare provider before use.
7. Is Calm Within™ pregnancy-safe?
If you are pregnant or breastfeeding, we recommend speaking with your doctor before use to ensure it is right for you.
8. Do I need to refrigerate it?
No. Calm Within™ is shelf-stable and does not require refrigeration. Store in a cool, dry place away from direct sunlight.
9. Does it contain allergens?
Calm Within™ is free from all 14 major allergens:
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celery
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cereals containing gluten (wheat, rye, barley, oats)
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crustaceans (prawns, crabs, lobsters)
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eggs
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fish
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lupin
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milk
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molluscs (mussels, oysters)
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mustard
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peanuts
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sesame
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soybeans
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sulphur dioxide and sulphites (>10 ppm)
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tree nuts (almonds, hazelnuts, walnuts, brazil nuts, cashews, pecans, pistachios, macadamias)
It is also free from artificial colors, added sugars, and GMOs, and is made to EU standards.
10. Is it vegan and cruelty-free?
Yes. Calm Within™ is 100% vegan, cruelty-free, and made without animal-derived ingredients, fillers, or contaminants.
11. Is the product Halal and Kosher?
Yes. All ingredients used in Calm Within™ are Halal and Kosher certified.
Scientific Advisory Board
Dr. Amine Zorgani
PhD
Microbiome Expert, with a Ph.D. in Life Sciences and Biotechnology
Dr. Alberto Barbara
PhD
Product Chemist with over 30 years of expertise in the beauty and cosmetic industry
Nicole Barnett
ND
Nutritional Scientist, Bachelor of Health Science, Nutrition and Naturopathic Medicine
Dr. Jennifer Channual
MD
A board-certified medical and cosmetic dermatologist
