The skin-gut-brain axis and our Triple Biotic™ advantage

Supporting your skin, gut, and brain with prebiotics, probiotics, and postbiotics

What is the microbiome?

The microbiome is the vast ecosystem of microorganisms—bacteria, fungi, viruses, and protozoa —that inhabit the digestive tract, skin, oral cavity, and other parts of the body. Among these, the gut microbiota is the most complex and diverse, housing trillions of microbes crucial for overall health.

These microorganisms interact with human cells to maintain gut health, modulate the immune system, and support metabolic and neurological functions. Research like the Human Microbiome Project underscores their foundational importance in maintaining systemic inflammation control, immune resilience, and more.

Role of the microbiome

Digestive & nutritional support

Microbes help break down dietary fiber and complex carbohydrates into short-chain fatty acids (SCFAs), which reinforce the intestinal barrier, reduce chronic inflammation, and nourish intestinal bacteria. SCFAs (like butyrate) help fuel gut cells, reduce inflammation, and support the integrity of the intestinal lining.

Immune system regulation

Around 70% of the body's immune cells reside in the gut. Gut microbes interact with the innate immune system, helping to differentiate between pathogens and host cells. This is crucial for preventing autoimmune diseases and maintaining immune responses.

Skin health

Microbiome-Skin axis: A well-balanced gut can influence the skin by reducing systemic inflammation. Additionally, the skin hosts its own unique microbiome that serves as a protective barrier, aka the skin microbiome. New research showed that maintaining a healthy bacterial balance can help mitigate skin disorders such as acne and eczema.

Brain health & mood

The gut-brain axis operates through the vagus nerve, signaling molecules, and microbial metabolites that influence psychological stress and neurotransmitter production. Imbalanced gut microbiota composition has been linked to mood disorders, while healthy gut microbes can support emotional well-being.

Metabolic health

Gut dysbiosis contributes to metabolic diseases such as obesity and insulin resistance. A diverse and balanced microbiome supports efficient energy extraction and weight management. 

Benefits of a balanced microbiome

A well-balanced microbiome helps support:

• Effective digestion and gastrointestinal health

• Immune modulation and resistance to bacterial infections

• Reduction in inflammatory skin conditions

• Enhanced nutrient absorption and overall skin health

• A resilient response to lifestyle factors like diet and stress

By understanding the microbiome’s foundational role, we can see why targeted strategies involving probiotics, prebiotics, and postbiotics (the “trifecta” of gut support) show promise in tackling issues at their microbial roots, ultimately benefiting gut, skin, and brain health together.

The Gut-Skin-Brain axis explained

Gut → Skin connection

A leaky intestinal barrier (a.k.a. leaky gut) allows toxins and pathogens to leak into the bloodstream, causing systemic inflammation and leading to skin symptoms such as acne or eczema. SCFAs produced by beneficial bacteria help counteract this by strengthening the skin barrier and reducing inflammation.

Gut → Brain connection: The “Second brain” hypothesis

The gut communicates with the brain via immune signals and neuroactive compounds. Dysbiosis can amplify psychological stress and anxiety, while a healthy gut can improve stress tolerance and cognitive clarity.

The skin & brain connection (via the gut)

The gut serves as the central hub. Stress can alter gut microbiota, leading to skin dysbiosis and compromised skin physiology. Chronic inflammation disrupts hormones and collagen, accelerating skin aging and dryness.

Trifecta of biotics: Probiotics, prebiotics & postbiotics

Understanding the foundational synergy between probiotics, prebiotics, and postbiotics is essential for supporting the gut-skin-brain axis and promoting whole-body wellness. These three types of biotics work together to improve gut microbiota composition, support immune system function, and influence both skin health and brain function.

Probiotics

Live microorganisms that, when administered in adequate amounts, confer a health benefit on the host. These beneficial bacteria help restore balance in the gut microbiome, modulate immune responses, and support gastrointestinal health.

Prebiotics 

Typically, non-digestible dietary fibers or complex carbohydrates that are selectively utilized by beneficial gut microbes. Prebiotics like inulin, fructooligosaccharides (FOS), and galactooligosaccharides (GOS) fuel the production of short-chain fatty acids, which help regulate inflammation and reinforce the intestinal barrier.

Postbiotics 

Inactivated microbial cells and their bioactive compounds, such as peptides and enzymes, that provide health benefits without needing to survive digestion. These compounds enhance immune responses, reduce chronic inflammation, and support skin homeostasis and healthy skin microbiota.

The Biologic Trifecta

Together, these three components create a closed-loop system that enhances gut microbiota balance, promotes skin elasticity, and modulates stress responses through the gut-brain-skin axis.

They are: 

• Clinically backed probiotic strains that support gut health and brain function.

• Targeted prebiotic fibers that fuel beneficial microbes and optimize the gut environment.

• Bioactive postbiotic compounds that regulate systemic inflammation and support skin barrier integrity.

These elements work together to:

• Enhance the production of short-chain fatty acids (SCFAs)

• Strengthen the intestinal barrier

• Promote microbial diversity in the gut microbiome

• Reduce inflammatory skin conditions such as acne and rosacea

• Support psychological stress resilience and emotional balance

Biotic spotlight 

Probiotics: Cerebiome® probiotic blend & Saccharomyces Boulardii

Our probiotic formulation is rooted in science and backed by clinical results. The blend includes Lactobacillus helveticus Rosell®-52, Bifidobacterium longum Rosell®-175 (3 Billion CFU), and Saccharomyces Boulardii CNCM I-1079 (300mg, 3 Billion CFU).

About the biotic 

These well-studied probiotic strains have been selected for their proven roles in modulating the gut-brain-skin axis and delivering targeted health benefits for digestive, emotional, and skin health.

The strains work synergistically to:

• Rebalance the gut microbiome, enhancing gut barrier function and reducing gut microbiota dysbiosis

• Regulate immune activity and support the innate immune system

• Improve gastrointestinal health and relieve stress-related digestive discomfort

• Enhance skin physiology, hydration, elasticity, and radiance by reducing systemic inflammation.

Clinical study highlights

Our in-house clinical trials demonstrate:

• Over 80% consumer satisfaction

• 91% of users would recommend the blend

• Improved perceived mood, emotional resilience, and psychological stress response

Skin benefits

• +21% facial skin hydration

• +12% improvement in skin firmness

• +18% body hydration

• +11% increase in skin elasticity

• -16% reduction in facial wrinkles

• +17% improvement in skin uniformity

• -22% forehead wrinkle reduction

• -10% reduction in crow’s feet

• +13% increase in skin radiance

• -31% reduction in perceived stress

Brain benefits

• Significant decrease in depressive scores and anhedonia

• Significant decrease in anxiety

• significant decrease in cortisol, a biomarker of stress

• Significant improvement of general stress-induced gastrointestinal score

• Significant improvement of stress-induced nausea and occasional abdominal pain

• 44% improvement of psychological signs related to occasional stress

• 74% experienced a reduction in psychological stress

• 41% reported improvements in sleep quality.

Gut benefits

• Boosted microbial diversity

• Strengthened intestinal barrier integrity

• Alleviated gut discomfort and symptoms related to irritable bowel syndrome

• 39% noted improved overall digestive health 

Prebiotics: Livaux®

Our prebiotic ingredient, Livaux®, is a clinically validated formulation derived from 300mg of freeze-dried golden kiwifruit powder. It is designed to selectively nourish beneficial bacteria, enhance microbial diversity, and optimize the gut microbiota composition without the digestive discomfort commonly associated with other prebiotics.

About the biotic

Livaux® is rich in polyphenols, high-methoxy pectin, and complex carbohydrates that fuel beneficial bacteria in the small intestine and colon. It is FODMAP-friendly, meaning it’s suitable for sensitive individuals and those managing irritable bowel syndrome. Unlike rapidly fermenting fibers, Livaux® ferments slowly along the entire colon, helping to avoid gas and bloating while promoting steady short chain fatty acid production.

This prebiotic compound supports overall gut health, improves gastrointestinal microbiome balance, and enhances the effectiveness of co-administered probiotic strains. It also plays a foundational role in reinforcing the intestinal barrier and reducing the risk of gut dysbiosis, thus lowering systemic inflammation and supporting immune responses.

Key features

• Made from whole kiwifruit with no chemical modifications

• Naturally FODMAP friendly, well-tolerated

• Rich in polyphenols and high-methoxy pectin

• Slow fermentation along the entire colon

Gut benefits

• Promotes a healthy gut microbiome and nourishes gut microbes

• Enhances the production of short-chain fatty acids to support gut barrier function

• Helps maintain microbiome balance and improve digestive tract resilience

• Supports better nutrient absorption, reducing the risks of gut-related autoimmune diseases

• Aids in relieving bloating and regulating bowel movements without irritation 

Postbiotics: Pomegranate Lactobacillus Ferment Lysate

Our postbiotic solution features Lactobacillus/Punica Granatum Fruit Ferment Extract — a next-generation bioactive designed to support skin health, calm inflammation, and restore skin homeostasis by working at the microbiome level.

True skin renewal starts with the microbiome — the living ecosystem that protects, regulates, and rebalances your skin. This advanced postbiotic complex goes beyond traditional exfoliants by delivering gentle enzymatic resurfacing while helping to harmonize stressed, sensitive, or imbalanced skin.

The ingredient is created through a natural fermentation process in which Lactobacillus, a beneficial probiotic strain, ferments pomegranate pulp. During fermentation, the fruit’s compounds are broken down into smaller, bioavailable molecules such as enzymes, peptides, and antioxidants. Once fermentation is complete, the bacteria are inactivated. What remains are potent postbiotics byproducts that help nourish the skin, strengthen the barrier, and support a healthy microbial balance.

Unlike live probiotics, which are unstable in skincare formulations, postbiotics are stable, safe, and highly effective, making them especially suitable for sensitive, acne-prone, or compromised skin.

About the biotic

Pomegranate Lactobacillus Ferment Lysate, a next-generation postbiotic, is made by fermenting pomegranate fruit with Lactobacillus. This process makes the key phytochemicals more readily available for enhanced benefits. This postbiotic is a multifunctional ingredient that acts as a natural exfoliant and renewal booster, which is ideal for both skin and hair care. It gently breaks down dead skin cells using proteolytic enzymes and has demonstrated a 26% boost in cellular turnover. Additionally, the presence of chlorogenic acid gives it anti-inflammatory and antimicrobial properties, making it ideal for calming sensitive or inflamed areas (for sensitive, acne-prone skin) while supporting a balanced skin microbiome.

Clinical study highlights

Research on the active has shown:

• +26% increase in cellular renewal (Dansyl Chloride Cell Renewal Study)

• 48.25% improvement in hydration within 24 hours

• 14% reduction in pigmentation for a more even skin tone

• 12.13% reduction in transepidermal water loss, reinforcing the skin barrier

• +10.1% reduction in visible spots (VISIA® analysis, 4-week clinical study)

• +11.5% reduction in UV-induced spots

• ↑ Significant improvement in skin moisture, brightness, elasticity, and collagen density

• Gentle enzymatic exfoliation — smooths without irritation

• Supports skin renewal by accelerating natural cell turnover

• Soothes inflammation — thanks to chlorogenic acid, naturally found in pomegranate

• Promotes microbiome balance through fermented bioactives

• Revitalizes the complexion — for clearer, smoother, more refreshed skin

• Clean formulation — water-extracted, preservative-free, and 88.5% biodegradable.

Further skin benefits

• Boosts skin elasticity and radiance — Promotes a visibly smoother, more luminous complexion

• Protects against harmful bacteria — Provides antimicrobial defense without disrupting the skin’s natural ecosystem

• Improves skin symptoms in those with inflammatory skin conditions, including acne, eczema, and rosacea

• Antimicrobial Protection — Naturally defends against bacteria with Leuconostoc/Radish Root Ferment

• Supports a Healthy Skin Microbiome — Helps restore and maintain balance for long-term skin health

Synergy for better skin, gut, and brain health

The trifecta of biotics in our Triple Biotic™ is designed to work synergistically to deliver comprehensive health benefits across the gut, skin, and brain. 

The probiotics, including Lactobacillus helveticus Rosell®-52, Bifidobacterium longum Rosell®-175, and Saccharomyces Boulardii CNCM I-1079, initiate the process by positively influencing the gut-brain axis, promoting a balanced mood and reducing stress, whilst also improving gut comfort and reducing digestive issues. 

Simultaneously, the prebiotic, Livaux®, supports these probiotics by fostering a healthy gut microbiome, ensuring they thrive and work effectively. Livaux's slow fermentation also helps to prevent gas and bloating, enhancing overall digestive comfort. 

Finally, the postbiotic works on the skin by providing gentle exfoliation and cellular renewal, thereby improving skin radiance and texture. The Pomegranate ferment lysate also has anti-inflammatory and antimicrobial properties that further support a balanced and healthy skin microbiome. 

Together, this combination creates a holistic approach to wellness, where a healthy gut supports mental and emotional well-being, while also contributing to the health and vitality of the skin.

Ready to experience the benefits of a balanced microbiome from the inside out?

Shop our science-backed skincare, gut health, and brain health solutions—each formulated with clinically studied biotics to support your skin, digestion, and emotional well-being.

Disclaimer: 

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.