What to expect from our Trifecta Collection

Your skin doesn’t operate in isolation — it reflects what’s happening inside your body, and especially your gut and brain. The skin-gut-brain axis is a complex communication network where stress, inflammation, microbiome balance, and hormone regulation all impact how your skin looks and functions.

When the gut microbiome is imbalanced, the intestinal barrier can weaken, allowing inflammation to spread systemically, often showing up as acne, redness, or premature aging. Chronic stress disrupts hormones and slows skin repair, while poor sleep and anxiety intensify gut issues and inflammation.

The Trifecta was formulated to restore this three-way connection — calming the brain, restoring the gut, and nourishing the skin, all at once.

We achieve this through our Triple Biotic strategy: a synergistic blend of prebiotics, probiotics, and postbiotics that targets the microbial roots of inflammation and skin dysfunction.

I. What makes the trifecta approach so unique?

Unlike traditional routines that only treat symptoms, our Trifecta works where balance begins: in the connection between your gut, brain, and skin. By restoring harmony across these systems, it helps lower inflammation, support resilience, and create the conditions for your skin to thrive naturally. The result is a foundation for skin transformation that lasts far beyond the surface.

• Prebiotics fuel beneficial microbes and support SCFA production to reduce inflammation.
• Probiotics help balance the gut-brain axis, reducing cortisol and supporting mental well-being.
• Postbiotics support the skin microbiome and reinforce the barrier for calmer, healthier skin.

By supporting all three systems, this routine doesn’t just reduce symptoms — it helps reset the environment in which your skin can thrive.

II. Why traditional skincare was never enough 

Topical products can hydrate, exfoliate, or soothe, but they don’t address:

• Internal stress that elevates cortisol and slows skin healing
• Gut dysbiosis that leads to inflammation, breakouts, and hormonal imbalances
• A compromised gut lining that leaks toxins into the bloodstream, aggravating the skin

That’s why topical-only routines often plateau.

The Trifecta bridges the gap by combining:

• Active, barrier-supportive topicals
• Gut-supporting supplement
• Brain-supporting Supplement
• Clinically studied Symbiotics of biotics that help balance the microbiome, modulate the immune system, and reduce systemic inflammation.

This inside-out strategy helps deliver faster, more sustainable, and more complete results across skin, mood, and gut health.

III. What our clinical studies reveal

When used consistently, the Trifecta has shown remarkable potential to transform not just your skin long term — but the systems that support it.

In our in-house clinical trial, participants experienced measurable improvements across the skin, gut, and brain. From hydration and skin texture to mood, digestion, and emotional resilience, the changes weren’t just visible — they were holistic.

• Early shifts were observed in sleep quality, gut comfort, and skin clarity
• Over time, participants reported smoother texture, improved tone, and more resilient skin
• Emotional well-being and stress responses improved in parallel with gut microbiome balance

The outcomes speak for themselves, but the real transformation happens step by step. Keep reading to see exactly what changes unfold in Week 1, Month 1, and Month 3 — and how the Triple Biotic™ approach delivers lasting results from the inside out.

IV. Purify & Comfort Face Cleanser: Detox & defend your skin 

The Purify & Comfort Face Cleanser is your Trifecta’s foundational step — a gentle yet effective formula that delivers real results:

Week 1

• Deeply cleanses without stripping skin
• Soothes irritation and reduces redness
• Reduces congestion and calms breakouts
• Promotes clearer, smoother skin texture
• Hydrates while cleansing — no tightness or dryness

Week 2–4

• Visibly brightens dull skin
• Clears clogged pores and minimizes breakouts
• Reduces skin redness, blotchiness, and irritation
• Helps rebalance oil production
• Smooths uneven texture and promotes skin clarity
• Reduces inflammation and soothes acne-prone areas
• Enhances absorption of active ingredients in your skincare routine

Week 8

• +26% boost in cellular turnover
• −77% Cutibacterium acnes count, helping reduce acne-causing bacteria
• Supports long-term glow and clarity with Vitamin C (Stay-C® 50)
• Reduces the appearance of blemishes and uneven skin tone
• Enhances elasticity and skin barrier repair
• Strengthens skin’s natural defenses against environmental stressors

Week 12

• −25% visible dark spots and hyperpigmentation
• Enhanced skin radiance and even tone
• Significant reduction in blemishes and acne
• Improved skin texture, smoothness, and firmness
• Strengthened barrier and hydration retention
• Supports clearer, healthier-looking skin across all skin types

Unlike harsh cleansers that disrupt your barrier, this formula respects your skin’s microbiome, boosts natural defenses, and preps your skin to absorb every benefit from the rest of your routine.

V. Brightening Radiance Super Serum: Protect + brighten

Our Brightening Radiance Super Serum is where transformation begins — targeting texture, tone, and long-term skin resilience with a potent blend of stabilized Vitamin C, BHA, postbiotics, and multi-weight hyaluronic acids:

Week 1: 

• Instantly hydrates and plumps skin with multi-weight hyaluronic acids
• Refines texture and calms redness with postbiotic and aloe-based formula
• Begins brightening and antioxidant protection with 10% stabilized Vitamin C (SAP)
• Clears congestion with 2% BHA — skin feels smoother and refreshed

Week 2–4: 

• 30% inhibition of UVA-induced squalene oxidation — reduces inflammation and acne triggers
• 40% reduction in UV-induced lipid peroxidation — improves glow and photoprotection
• Boosts skin tone clarity and reduces pore congestion
• Begins stimulating collagen and hyaluronic acid production
• Enhances antioxidant defense and supports skin renewal

Week 8: 

• 550% increase in collagen I & III — visibly firmer, more elastic skin
• 105% total collagen synthesis — strengthens skin structure
• 174% increase in hyaluronic acid production — deep hydration and suppleness
• 77% reduction in Cutibacterium acnes — fewer blemishes, calmer skin
• 77% improvement in skin smoothness and texture
• 57% inhibition of melanin synthesis — brighter, more even skin tone

Week 12: 

• 25% visible reduction in dark spots and hyperpigmentation
• 100% wrinkle depth reduction in select participants
• 16% wrinkle reduction within 30 minutes of use
• Overall improvements in radiance, firmness, hydration, and barrier strength
• Skin appears clearer, more lifted, and visibly rejuvenated

Fast-absorbing and non-irritating, this serum bridges gentle exfoliation with deep nourishment — making it a key player in building skin that’s not just bright, but resilient from the inside out.

VI. Calm & Hydrate Oil-Free Moisturizer: Rebuild + restore

Our Calm & Hydrate Oil-Free Moisturizer is the final topical step in the Trifecta, designed to deeply hydrate, soothe, and strengthen your skin barrier — without clogging pores or leaving a greasy finish:

Week 1:

• Delivers instant, non-greasy hydration through an 80% aloe vera base
• Soothes redness and irritation with chamomile and postbiotic ferment
• Rebalances and softens oily or sensitive skin without clogging pores
• Begins reducing tightness, dryness, and dehydration
• Improves barrier comfort with ceramides and squalane

Week 2:

• +30% improvement in skin hydration
• +200% increase in skin’s water content
• +25% enhanced moisture retention (amino acids + hyaluronic acid)
• −20% wrinkle reduction (VISIA® validated)
• −20% reduction in fine lines
• Skin feels smoother, plumper, and more resilient

Week 4–8: 

• Reinforces the skin’s lipid matrix with Ceramides (NP, EOP, AP)
• Repairs and strengthens the skin barrier to reduce transepidermal water loss (TEWL)
• Improves elasticity and long-lasting hydration through biomimetic amino acids
• Visibly reduces roughness and enhances skin tone clarity
• Protects against inflammation, stress, and pollution-related aging

Week 12: 

• Skin appears firmer, more balanced, and deeply nourished
• Long-term barrier resilience is improved across all skin types
• Fine lines, texture, and dehydration signs are visibly minimized
• Skin looks calm, youthful, and naturally radiant

This moisturizer doesn’t just hydrate, it actively repairs and reinforces your skin’s natural defenses, locking in everything you’ve achieved with Steps 1 and 2.

VII. Clarify Within supplement: Clearer skin from the gut out

Clarify Within is a daily gut supplement designed to clear skin by restoring digestive harmony, calming internal inflammation, and improving the way your body responds to stress — all key factors in acne, redness, and skin sensitivity:

Week 1–2: Daily stress begins to ease, mood feels more stable, and gut discomfort starts to improve. Many users report feeling calmer, less bloated, and more energized — early signs that gut-brain balance is kicking in. In the first two weeks, you can expect the Clarify Within supplement to deliver:

• Lowered cortisol & increased calmness: With 30 mg of Safr’Inside™, salivary cortisol levels drop within hours, easing acute stress responses. This helps reduce physiological stress and supports greater mood stability. 

Studies supporting the effect PubMed: 37447245; PMC: 10346743

• Increased emotional regulation (HPA Modulation): With Safr’Inside™, calmness and emotional control improve within 1–3 hours, helping to restore immediate HPA-axis balance. This promotes emotional ease and resilience under stress.

Studies supporting the effect PubMed: 33598475

• Increased serum Vitamin D: With 26 µg (1,040 IU) of VegD3®, serum 25(OH)D levels rose by 77% in just 7 days, based on the clinical reference dose. This rapid correction of deficiency supports both the immune and nervous systems.
   
• Increased mood & faster sleep onset: With 30 mg/day Safr’Inside™, mood improves and sleep latency is reduced within 1–2 weeks. This leads to calmer evenings and quicker, more restful sleep.

Studies supporting the effect PubMed: 33598475

• Increased probiotic colonization begins: With 3B CFU Cerebiome® and 3B CFU Saccharomyces boulardii, the gut-brain axis begins to shift, supporting both stress reduction and digestive balance. Early benefits include greater gut comfort, improved sleep quality, and reduced anxiety.

Studies supporting the effect Cerebiome®: PubMed: 21983070; S. boulardii: PubMed: 19083380

• Increased moisture barrier & lipid support: With 640 mg Ahiflower® and 110 mg Borage Oil, lipid synthesis and skin hydration are enhanced. This leads to a softer, more resilient skin barrier that better protects against dryness and irritation.

Studies supporting the effect Ahiflower: PubMed: 28287415; Borage Oil: PubMed: 24553997

Week 4: Breakouts and oiliness begin to decrease. Gut comfort improves further, with more regular digestion and less bloating. Sleep quality and emotional stability continue to progress as internal inflammation declines. After the 4th week: 

• Decreased acne severity (87% improvement): With 300 mg/day of Saccharomyces boulardii, 87% of participants experienced visibly clearer skin after 4–5 weeks. This improvement was linked to reduced inflammation and more balanced skin.

Studies supporting the effect PMC: 3038963

• Decreased stress, anxiety & mood symptoms: With Cerebiome®, participants experienced a 25% reduction in anxiety, a 15% reduction in depression, and a 20% reduction in stress within 30 days. These changes support improved emotional balance and greater resilience.

Studies supporting the effect PubMed: 21983070

• Increased skin hydration & firmness: With Cerebiome®, participants experienced improvements in skin hydration, reduced wrinkle depth, and better sleep within 4 weeks. The result is visibly plumper, firmer skin paired with deeper rest.
   
• Increased sleep quality (Insomnia relief): With Safr’Inside™, adults with moderate insomnia experienced improvements in both sleep onset and sleep duration. This led to longer, deeper, and more restorative rest.
   
• Decreased GI discomfort & inflammation: With Saccharomyces boulardii, participants experienced improvements in IBS-related quality of life and reductions in gut inflammation. This translated to less bloating, smoother digestion, and reduced GI distress.

Studies supporting the effect PubMed: 21301358;  PubMed: 24722560

• Decreased inflammatory skin conditions: With 1,500 mcg RAE of Vitamin A, participants saw reductions in acne and improvements in epidermal barrier repair. This led to fewer blemishes and a stronger, more resilient skin barrier.

Studies supporting the effect PubMed: 33494277; PubMed: 35674761

• Increased emotional resilience & HRV: With 30 mg/day of Safr’Inside™, participants experienced improvements in heart rate variability (HRV), mood resilience, and calm over 4–8 weeks. This supported better stress adaptation and a steadier, more focused sense of calm.

Studies supporting the effect PubMed: 33598475

• Decreased SIBO markers & gut overgrowth: With 300 mg/day of Saccharomyces boulardii, hydrogen breath test markers were reduced and gut comfort improved in SIBO-positive IBS-D patients. This resulted in less bloating, better stool quality, and stronger microbiota support.

Studies supporting the effect Pubmed 36630947

• Increased anti-inflammatory Cytokines & gut barrier repair: With 300 mg of Saccharomyces boulardii, cytokine profiles improved and gut histology showed signs of repair. This supported stronger barrier integrity and better inflammation control.

Studies supporting the effect  PubMed: 24722560

• Increased vitamin A barrier & acne support: With 1,500 mcg RAE of Vitamin A, epithelial barrier function and overall skin integrity were enhanced. This led to calmer skin and fewer breakouts.

Studies supporting the effect PubMed: 33494277; PubMed: 35674761

• Increased microbiome diversity & SCFA: With Ahiflower® and Saccharomyces boulardii, SCFA production increased alongside greater microbiome diversity. This supported improved digestion, clearer skin, and healthier gut-brain signaling.

Studies supporting the effect PubMed PMC: 11067990; PMC: 9023356

• Increased microbiota recovery & mucus repair: With 300 mg/day of Saccharomyces boulardii, microbial diversity and SCFA levels improved following dysbiosis, while gut lining structure showed signs of repair. This resulted in a healthier microbiome, better stool quality, and a stronger barrier.

Studies supporting the effect PubMed 26392857

Week 8: Results become visibly measurable — 85% of users reported increased skin hydration, 82% noticed smoother skin with improved texture, and 76% saw a reduction in the appearance of fine lines. 79% also experienced noticeable improvements in mental well-being, with clearer skin, better sleep, and reduced anxiety. After week 8: 

• Increased BDNF & neuroplasticity: With Cerebiome®, adults with mild-to-moderate depression experienced significant increases in serum BDNF levels. This supported greater neuroprotection, enhanced neuroplasticity, and improved mood regulation.

Studies supporting the effect PubMed: 32989186

• Increased Omega-3 conversion (EPA & DPA): With 640 mg of Ahiflower®, EPA levels increased within 28 days. This supported improved inflammatory response and healthier cell membrane function.

Studies supporting the effect PMC: 4709838

• Increased gut–brain–skin axis modulation: With probiotics, Ahiflower®, and vitamins, improvements were seen in skin health, gut permeability, and inflammation. This promoted balanced systemic function and stronger microbiome resilience.

Studies supporting the effect PubMed: 31892611; PubMed: 33494277

• Decreased gut inflammation markers: With Saccharomyces boulardii (750 mg in studies, 300 mg in your formula), gut inflammation decreased as IL-8 and TNF-α lowered and IL-10 increased. This resulted in better immune balance and a calmer gut.

Studies supporting the effect PubMed: 24722560

• Increased skin barrier & texture: With Ahiflower® and Borage Oil, lipid barrier function and elasticity improved. This led to smoother, more hydrated, and resilient skin.

Studies supporting the effect PubMed: 24553997; PubMed: 28287415

• Increased microbiome diversity & gut comfort: With omegas and probiotics, SCFA production rose alongside the growth of beneficial microbial species. This supported enhanced digestion, clearer skin tone, and better emotional regulation.

Studies supporting the effect PMC: 5672330; PMC: 9023356; PMC: 11067990

• Increased stool form & microbial balance: With 300 mg/day of Saccharomyces boulardii, stool consistency improved, and healthy mucus-associated microbiota were restored in chronic diarrhea. This reduced discomfort and normalized bowel function.

Studies supporting the effect PubMed: 18416850

Week 12: Acne severity continues to decline, with enhanced skin tone, firmness, and hydration. Gut function and microbiome diversity are significantly improved, supporting long-term hormonal balance, reduced inflammation, and a calm, resilient complexion. After week 12:

• Increased HRV, resilience & long-term calm: With Safr’Inside™, participants experienced improvements in mood, heart rate variability (HRV), and sustained calm over time. This supported stronger stress tolerance and a more balanced mood.

Studies supporting the effect  PubMed: 33598475

• Decreased systemic inflammation & gut permeability: With Vitamin D3 and K2, inflammation was reduced while the gut barrier was strengthened. This promoted greater gut resilience and lowered immune reactivity.

Studies supporting the effect  PMC: 11767688

• Increased gut barrier & microbiota rebalance: With Vitamins A, D3, and K2, tight junction repair was supported alongside a healthier microbial balance. This led to clearer skin, improved digestion, and better stress modulation.

Studies supporting the effect PubMed: 33494277; PubMed: 31892611

Clarify Within doesn’t just treat the skin; it helps reset the internal systems that influence how your skin behaves and heals, creating visible, whole-body transformation from the inside out.

VIII. Calm Within supplement: Mind & body harmony

Calm Within is a daily brain supplement designed to rebalance your nervous system, sharpen mental clarity, and support skin health by targeting the stress signals that affect your brain, gut, and complexion. From the very first dose, it promotes a calmer mind, better focus, and a subtle shift toward inner ease that builds with consistent use.

Within Hours to Week 2: Calm sets in quickly, fatigue begins to fade, physical energy improves, and skin hydration and radiance start to visibly increase. In the first two weeks, you can expect our Calm Within supplement to: 

• Decreased cortisol & increased calm: With 250 mg of Sensoril® Ashwagandha, salivary cortisol levels were reduced and stress perception improved within hours.

Studies supporting the effect PubMed: 23439798 

• Increased relaxation & improved cognitive clarity: With 100 mg of L-Theanine, alpha brain wave activity increased, promoting calm alertness without sedation.

Studies supporting the effect PubMed: 18296328

• Increased mood & emotional regulation: With 100 mg of Magnesium Bisglycinate and 120 mcg of Selenium, participants reported improved mood, better sleep, and reduced perceived stress in chronically stressed adults.

 Studies supporting the effect PubMed: 33864354 | PMC: 8420003

• Increased cognitive focus & verbal fluency: With 100 mg of L-Theanine, executive function and mental accuracy improved during periods of cognitive stress.

Studies supporting the effect  PubMed: 31623400

• Decreased cortisol & increased calmness: With 250 mg of Sensoril® Ashwagandha, cortisol and stress symptoms were significantly reduced in under 2 weeks. This supported improved resilience to daily stressors and enhanced mood stability.

Studies supporting the effect PubMed: 31769411

• Decreased sleep latency & increased sleep quality: With 100 mg of L-Theanine, participants fell asleep more quickly and experienced better overall sleep quality.

Studies supporting the effect PubMed: 32121094

• Increased antioxidant activity begins: With 6 mg of Astaxanthin, antioxidant protection was initiated within 2–4 weeks, reducing skin oxidation and enhancing photoprotection.

Studies supporting the effect PubMed: 30274254

• Increased gut prebiotic activation: With 300 mg of Livaux®, levels of Faecalibacterium prausnitzii, a key butyrate-producing microbe, increased within 2 weeks. This supported greater SCFA production, microbiome diversity, and digestive comfort.

Studies supporting the effect PMC: PMC5672330

• Increased gut comfort & bowel regularity: With 300 mg of Livaux®, stool consistency and gut motility improved, while bloating decreased in both constipated and healthy individuals.

Studies supporting the effect PubMed: 29113116

• Increased energy & decreased fatigue: With 100 mg of CoQ10 (Ubiquinone), mild fatigue was significantly reduced and physical performance improved in healthy adults.

Studies supporting the effect PubMed: 32575770

• Decreased stress, anxiety & mood symptoms: With Sensoril® and Magnesium, participants experienced significant improvements in anxiety, depression, and sleep scores.

Studies supporting the effect PubMed: 23439798 | PMC: 8632422

• Increased skin hydration & elasticity: With 6 mg of Astaxanthin, hydration and elasticity improved while wrinkle depth decreased in middle-aged participants.

Studies supporting the effect PubMed: 22428137

• Decreased inflammatory skin conditions: With 15 mg of Zinc and 120 mcg of Selenium, acne and eczema symptoms were reduced, supporting a healthier epidermal barrier.

Studies supporting the effect PubMed: 31932842 | PMC: 4120804

• Increased cognitive function & executive control: With Quatrefolic® (400 mcg DFE), neurotransmitter synthesis was supported and cognition improved in adults with mild cognitive impairment.

Studies supporting the effect PubMed: 21780182

Week 4: Stress and anxiety levels begin to drop noticeably. Users report a more balanced mood, better cognitive function, and overall improvements in skin health. Internal inflammation and oxidative stress markers continue to decline. After 4 weeks: 

• Decreased cortisol & increased calmness: With 250 mg of Sensoril® Ashwagandha, cortisol levels were significantly reduced and stress perception improved within 2 weeks. This supported greater resilience to daily stressors and enhanced mood stability.

Studies supporting the effect PubMed: 31769411

• Decreased sleep latency & increased sleep quality: With 100 mg of L-Theanine, time to fall asleep decreased and subjective sleep quality improved. This resulted in quicker sleep onset and deeper, more restorative rest.

Studies supporting the effect PubMed: 32121094

• Decreased fatigue & increased energy: With 100 mg of CoQ10, mild fatigue was significantly reduced while energy stability and performance improved. This provided more sustained energy and less exhaustion.

Studies supporting the effect PubMed: 32575770

• Increased gut comfort & bowel regularity: With 300 mg of Livaux®, levels of Faecalibacterium prausnitzii increased, leading to better stool frequency and reduced bloating. This enhanced digestive regularity and overall gut comfort.

Studies supporting the effect PubMed: 29113116 | PMC: PMC5672330

• Increased prebiotic activity & SCFA production: With 300 mg of Livaux®, microbiota modulation initiated greater SCFA production within 2 weeks. This strengthened gut-brain communication and supported microbiome diversity.

Studies supporting the effect PMC: 5672330

• Increased antioxidant activity begins: With 6 mg of Astaxanthin, oxidative stress in the skin was reduced and photoprotection improved. This offered early defense against photoaging and inflammation.

Studies supporting the effect PubMed: 30274254

• Increased skin hydration & elasticity: With 6 mg of Astaxanthin and 100 mg of CoQ10, skin hydration, elasticity, and pigmentation improved within 4–6 weeks. This led to visibly plumper, firmer, and more radiant skin.

Studies supporting the effect PubMed: 22428137;  PubMed: 30301271

• Increased mood balance: With 250 mg of Sensoril® and 100 mg of L-Theanine, mood improved, anxiety decreased, and calm cognition was supported. This promoted greater emotional ease and mental clarity.

Studies supporting the effect PubMed: 22198463; PubMed: 21762294

• Decreased oxidative stress & skin inflammation: With 120 mcg of Selenium and 15 mg of Zinc, inflammatory and oxidative markers in the skin were reduced. This resulted in calmer, clearer skin and stronger cellular repair. 

Studies supporting the effect PubMed: 17482888

• Decreased stress, anxiety & mood symptoms: With Sensoril® and Magnesium, perceived stress and anxiety significantly decreased within 30 days.

Studies supporting the effect PubMed: 23439798 | PMC: 8632422

• Decreased inflammatory skin conditions: With Zinc and Selenium, acne severity decreased and immune regulation improved in chronic skin conditions. This supported a clearer complexion and healthier skin defenses. 

Studies supporting the effect PubMed: 31932842 | PMC: 4120804

• Increased cognitive function & executive control: With Quatrefolic® (400 mcg DFE), cognition improved and brain atrophy was reduced in adults with mild cognitive impairment.

Studies supporting the effect PubMed: 21780182

Week 6–8: Mental fatigue lifts. Cognitive functions like memory, attention, and processing speed improve, making daily tasks feel easier and more focused. Skin feels more hydrated and smooth, while digestive comfort increases as gut microflora begin to rebalance. In weeks 6 to 8th: 

• Increased tight junctions & gut barrier repair: With 15 mg of Zinc, 120 mcg of Selenium, and 300 mg of Livaux®, epithelial barrier integrity improved and gut permeability decreased by supporting tight junction proteins and microbial balance. This led to lower gut-driven inflammation and stronger microbiome resilience.

Studies supporting the effect PubMed: 19152059 

• Increased cellular energy & mitochondrial health: With 100 mg of CoQ10, mitochondrial ATP production and antioxidant capacity were enhanced in energy-demanding tissues such as the skin, brain, and gut. This supported improved stamina, mental clarity, and resilience against age-related decline.

Studies supporting the effect PubMed: 17914161

• Increased immune modulation: With Quatrefolic® (400 mcg B9), Zinc, Selenium, and Sensoril®, pro-inflammatory cytokines decreased while adaptive immune balance was enhanced. This supported a more balanced inflammatory response and greater stress immunity.

Studies supporting the effect PubMed: 35983607

• Increased gut microbiome diversity & barrier function: With 300 mg of Livaux®, Zinc, and Magnesium, microbial diversity increased and gut lining structure was reinforced, leading to higher SCFA production. This resulted in reduced bloating, better digestion, and greater microbiome stability.

Studies supporting the effect PMC: 3724376 | PMC: 5672330

• Increased antioxidant activity & skin protection: With 6 mg of Astaxanthin and 100 mg of CoQ10, UV-induced damage was reduced while skin elasticity and moisture improved. This provided visible defense against photoaging and enhanced antioxidant support.

Studies supporting the effect PubMed: 34578794 

• Increased brain-derived neurotrophic factor (BDNF): With 250 mg of Sensoril® Ashwagandha, serum BDNF levels rose and neuroplasticity improved, strengthening stress resilience and learning. This supported greater mood stability, cognitive performance, and adaptability to stress.

Studies supporting the effect PubMed: 32989186

• Increased SCFA production & anti-inflammatory response: With 300 mg of Livaux® and Magnesium Bisglycinate, SCFA-producing microbes like F. prausnitzii were supported alongside mucosal anti-inflammatory signaling. This led to reduced gut-driven inflammation and better gut-skin-brain communication.

Studies supporting the effect PMC: PMC5672330

• Increased skin glow & pigmentation reduction: With 6 mg of Astaxanthin and 100 mg of CoQ10, skin tone brightened, age spots reduced, and photoprotection improved by Week 8. This delivered a more radiant, even complexion with stronger defense against oxidative stress.

Studies supporting the effect PubMed: 30274254

• Increased skin barrier & texture: With Zinc, Selenium, and Astaxanthin, collagen integrity improved, pigmentation was reduced, and skin hydration strengthened. This resulted in smoother, firmer skin with less inflammation and irritation.

Studies supporting the effect PubMed: 30075283 

• Increased methylation & mood regulation: With 400 mcg of Quatrefolic®, MTHFR polymorphisms were bypassed to support neurotransmitter production and stabilize mood. This promoted improved emotional regulation and clearer cognition.

Studies supporting the effect PubMed: 35999905

• Increased BDNF & cognitive resilience: With Sensoril® and CoQ10, BDNF levels increased alongside improvements in verbal fluency and working memory. This supported stronger cognitive resilience and performance under stress.

Studies supporting the effect PubMed: 32989186 

Week 12: Skin elasticity, firmness, and smoothness show visible improvements. Mental clarity deepens — users describe a steady, sustained calm, with sharper thinking, improved mood, and a noticeable lift in both emotional and physical resilience. After 12 weeks: 

• Increased HRV, long-term calm & resilience: With 250 mg of Sensoril® and 100 mg of Magnesium Bisglycinate, parasympathetic tone and HRV improved, supporting greater emotional resilience over time. This promoted sustained calm, balanced mood, and stronger stress recovery.

Studies supporting the effect PubMed: 33598475 | PMC: 8632422

• Decreased systemic inflammation & skin redness: With 120 mcg of Selenium, 15 mg of Zinc, and 100 mg of CoQ10, TNF-α and oxidative stress were reduced, leading to clearer skin and less redness. This combination also supported stronger immunity and lower inflammatory reactivity.

Studies supporting the effect PubMed: 30301271 | PMC: 6266238

• Increased brain performance & neuroprotection: With 6 mg of Astaxanthin, 100 mg of CoQ10, and 120 mcg of Selenium, cognitive function and memory improved while neurons were protected from oxidative damage. This supported sharper focus, clearer thinking, and defense against cognitive decline.

Studies supporting the effect PubMed: 29610561 | PMC: 9003735

• Increased collagen support & skin firmness: With Astaxanthin, CoQ10, and Zinc, plus Vitamin C when paired topically, collagen synthesis increased while wrinkle depth decreased. This resulted in smoother texture, firmer skin, and visible rejuvenation.

Studies supporting the effect PubMed: 30301271 | PMC: 6266238

• Increased cognitive function & clarity: With 120 mcg of Selenium, cognition and mood stability improved in adults, with particularly strong benefits in those over age 60. This supported better memory, clearer focus, and greater mental stamina.

Studies supporting the effect PubMed: 37180486

• Decreased inflammatory markers & enhanced antioxidant defense: With Zinc, Selenium, and Astaxanthin, TNF-α, IL-6, and oxidative burden decreased across the skin, gut, and brain. This promoted greater cellular protection, vitality, and fewer inflammatory triggers.

Studies supporting the effect PubMed: 17482888 | PubMed: 30301271

By supporting brain function, gut health, and skin integrity all at once, Calm Within delivers total mind-body balance — helping you feel better, think clearer, and glow from within.

IX. The Trifecta in motion: What 12 weeks of consistency delivers

Week 1: First shifts, inside and out

• Hydration + calm from the first application: Your topical routine (cleanser, serum, and moisturizer) begins replenishing moisture and soothing irritation. Skin feels more balanced, with early signs of inflammation reduction.
   
• Digestive and mental ease: Internally, the Triple Biotic™ blends (pre-, pro-, and postbiotics) start shifting the gut microbiome. This supports digestion, relieves bloating, and begins regulating stress via the gut-brain axis.
   
• Increased clarity and energy: Many users report improved focus, lower fatigue, and a subtle sense of calm — early signs of nervous system regulation and lowered cortisol.

This is the foundation phase, subtle but important shifts are taking place, preparing the body for deeper transformation.

Month 1 (Weeks 2–4): The axis in motion

• Visible skin improvements: Acne, oiliness, and redness begin to ease. Pores appear more refined, and skin looks brighter and more even.
   → Up to 87% of users report visibly improved acne by Week 4.
   
• Stronger microbiome + digestive comfort: Gut discomfort continues to decline. Prebiotics feed beneficial bacteria, probiotics promote balance, and postbiotics support intestinal barrier function — key to calming inflammation.
   
• Mood, sleep, and focus: Many notice better emotional resilience, more restful sleep, and clearer mental focus — the result of gut-brain signaling and cortisol regulation.
   
• Barrier support + glow: The skin barrier continues strengthening, with increased hydration and the first signs of collagen and hyaluronic acid production.

The trifecta starts working together visibly and tangibly — gut, skin, and brain progress as one system.

Month 3 (Weeks 8–12): Full-body resilience

• Clinically measured outcomes
  • 77% reduction in Cutibacterium acnes
  • 85% reported increased skin hydration
  • 82% saw improved texture
  • 76% noticed fewer fine lines
  • 79% experienced enhanced mental well-being
     
• Skin transformation: Texture, tone, elasticity, and radiance all improve. Postbiotics help strengthen the skin’s barrier and accelerate cellular renewal. Dark spots fade, and hydration levels are visibly higher.
   
• Gut rebalanced: Microbial diversity improves, inflammation drops, and digestion feels consistent. Reduced bloating, improved bowel regularity, and better nutrient absorption are common.
   
• Mental clarity + mood: Users report more stable moods, sharper focus, and fewer signs of stress — with cortisol, homocysteine, and oxidative stress markers all trending down.
   
• Sustained glow from within: The trifecta has established a healthy rhythm across the body’s systems — what once felt out of balance now feels calm, consistent, and clear.

This is where the full power of the Trifecta is felt — lasting resilience, inside and out. Shop our full skin-gut-brain collection. 

Disclaimer: 
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.